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阿尔茨海默氏症成像联盟

Leah S Varghese1, Lisa M Taylor1, Elizabeth A Thomas1

  • 1University of California, Irvine, Irvine, CA, USA.

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概括
此摘要是机器生成的。

一种新的超值方法改善了血ptau-217和早期阿尔茨海默氏症tau病理之间的相关性,在认知上没有受损的个体中. 这种敏感的方法可以检测到在内皮层的积累,即使没有β-粉样蛋白.

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科学领域:

  • 神经科学是一个神经科学.
  • 生物标志物 生物标志物
  • 阿尔茨海默氏症疾病研究研究

背景情况:

  • 血ptau-217显示出阿尔茨海默氏症病理检测的前景.
  • 之前的研究发现,在认知不受损 (CU) 个体中,血ptau-217和tau-PET之间的相关性较弱.
  • 基于平均标准化吸收值比率 (SUVR) 的兴趣区域 (ROI) 分析可能缺乏对微妙,早期tau聚合的敏感性.

研究的目的:

  • 重新检查血ptau-217与中间叶 (MTL) 中早期tau聚合之间的关系.
  • 为了研究这种关系作为粉样蛋白-β (Aβ) 状态在CU老年人的函数.
  • 为了比较一个超值的基于voxel的方法与传统的平均SUVRROI分析.

主要方法:

  • 来自ADNI的142CU老年人与血ptau-217和18F-Flortaucipir-PET数据的分析.
  • 将SUVR值 (1.1-1.4) 应用于tau-PET数据,以计算关键MTL地区 (EC,PHC,Amyg,FUS) 的超值voxels的百分比.
  • 使用斯皮尔曼等级相关性对每个ROI的超值分析与平均SUVR进行比较.

主要成果:

  • 在Aβ-参与者中,内腔皮层 (EC) 的超值方法 (SUVR ≥1.4) 与血ptau-217 (ρ=0.25,p=0.011) 显示出最强的相关性.
  • 在Aβ+参与者中,超值方法 (SUVR ≥1.4) 相当于欧洲共同体中的平均SUVR,但在检测晚期MTL区域 (Amyg,PHC,FUS) 的tau-PET方面更为敏感.
  • 平均SUVR显示Aβ-的相关性较弱,不显著,并且未能在Aβ+参与者中检测到晚期MTL区域的显著关联.

结论:

  • 在尚未和病理的区域中,超值方法在检测早期tau聚合时比平均SUVR更为敏感.
  • 血ptau-217与CU个体的EC中超值tau-PET相关,即使没有Aβ.
  • 晚期MTL区域的血ptau-217和超值tau-PET之间的关系与Aβ病理出现,突出时间动态和敏感生物标志物检测的实用性.