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阿尔茨海默氏症成像联盟

Deepti Putcha1, Michael J Properzi2, Kathryn V Papp3

  • 1Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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PubMed
概括
此摘要是机器生成的。

主观认知能力下降,特别是在视觉空间能力方面,可能表明临床前阿尔茨海默病 (AD). 这项研究发现,自我报告的认知能力不受损害的个体的视觉空间困难与粉样蛋白和蛋白生物标志物相关,这表明一种潜在的早期检测方法用于非典型的AD变体.

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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是一门学科.
  • 生物标志物 生物标志物

背景情况:

  • 在认知无障碍 (CU) 个体中,主观认知衰退 (SCD) 是阿尔茨海默病 (AD) 进展的危险因素.
  • 目前关于SCD的研究主要集中在记忆问题上,忽视了其他AD表型,如后皮层缩 (PCA).
  • 需要方法来识别临床前阿尔茨海默病患者,这些人可能会发展出非典型的阿尔茨海默病变体,如PCA.

研究的目的:

  • 调查主观视觉空间衰退与CU个体认知功能和生物标志物之间的关联.
  • 探索日常认知尺度 (ECOG) 视觉空间子尺度在识别早期AD病理学的实用性.
  • 确定主观视觉空间关注是否可以预测非典型AD变体的发展.

主要方法:

  • 分析了253个CU参与者对ECOG视觉空间子级别的自我报告反应.
  • 探索ECOG视觉空间分数,客观认知测试和粉样蛋白PET阳性 (PiB+) 之间的关联.
  • 进行全皮层tau PET一般线性模型,以检查主观视觉空间衰退与tau负担之间的联系.

主要成果:

  • 4%的CU参与者报告视觉空间困难,这些困难与年龄,性别,教育或MMSE得分无关.
  • ECOG视觉空间得分与客观视觉空间认知或MMSE没有相关性.
  • 视觉空间问题与更高的粉样蛋白负担 (PiB +) 和右半球沉积有关,这些地区与临床前阿尔茨海默病有关.

结论:

  • 主观视觉空间衰退,在健康老龄化中不常见,存在于CU个体的一个子集中.
  • ECOG视觉空间子级可能有助于检测早期的AD病理,包括视觉空间衰退以及记忆问题.
  • 识别主观视觉空间衰退的个体可能有助于早期诊断和治疗非典型的AD变体.