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阿尔茨海默氏症成像联盟

Tevy Chan1,2,3, Seyyed Ali Hosseini1,2,3, Arthur C Macedo1,2,3

  • 1Montreal Neurological Institute, Montreal, QC, Canada.

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概括
此摘要是机器生成的。

脑脊液 (CSF) 清除阿尔茨海默病 (AD) 生物标志物如p-tau181和神经丝光链 (NfL) 的损害与粉样蛋白病理有关. 这种清除赤字独立于血脑屏障 (BBB) 功能障碍.

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科学领域:

  • 神经科学是一个神经科学.
  • 生物化学 生化学
  • 老年学是一门学科.

背景情况:

  • 血与脑脊液 (CSF) 生物标志物的比率可能表明从中枢神经系统 (CNS) 的清除.
  • 这种清除与阿尔茨海默氏病 (AD) 中的血脑屏障 (BBB) 变化之间的关系尚不清楚.
  • 研究血/中枢神经的生物标志物比率和BBB的透性对于理解AD的发病过程至关重要.

研究的目的:

  • 为了检查血和CSF神经纤维光链 (NfL) 和p-tau181在整个AD频谱中的个体之间的比率.
  • 为了确定这些生物标志物比率和BBB透性之间的关系.
  • 探索CSF清除在AD生物标志物积累中的作用.

主要方法:

  • 分析了102名参与老龄化和痴呆症转化生物标志物 (TRIAD) 队列的数据.
  • 使用Lumipulse G1200测量了NfL和p-tau181的血和CSF水平.
  • 计算了CSF/血清白蛋白系数作为BBB完整性的标志物,并使用斯皮尔曼的相关性来评估与粉样蛋白PET SUVR和白蛋白系数的关联.

主要成果:

  • 质p-tau181/CSF p-tau181和质NfL/CSF NfL比率在粉样蛋白阳性,阳性 (A+T+) 个体下降,表明CSF清除受损.
  • 增加的粉样蛋白负担与降低的血/CSF生物标志物比率相关.
  • 血/CSF生物标志物比率和白蛋白系数之间没有发现显著的相关性,这表明CSF清除独立于BBB完整性.

结论:

  • 脑脊液清除障碍有助于AD生物标志物在中枢神经系统中的积累.
  • 这种受损的清除与BBB功能障碍无关.
  • 中枢神经清除代表了阿尔茨海默病的潜在治疗标,需要研究加强中枢神经系统的排水.