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阿尔茨海默氏症成像联盟

Trevor A Chadwick1, Corrina S Fonseca1, Jenna N Adams2

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此摘要是机器生成的。

基底前脑和脑内皮层的功能连接预测了tau的传播. 内皮层显示出更强有力的证据,表明功能连接介导的在大脑中的沉积.

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科学领域:

  • 神经科学是一个神经科学.
  • 神经成像是一种神经成像.
  • 阿尔茨海默氏症疾病研究研究

背景情况:

  • 病理性蛋白聚合物以活动依赖的方式在大脑中传播.
  • 之前的研究表明,的传播可以在体内检测到与内腔皮层 (ERC) 连接的区域.
  • 这项研究调查了基础前脑 (BF) 的功能连接 (FC) 是否也是tau积累的早期地点,也预测了tau传播模式.

研究的目的:

  • 为了确定基底前脑 (BF) 的功能连接 (FC) 是否预测沉积模式.
  • 为了比较ERC和BF功能连接在tau传播的预测能力.
  • 探索FC强度和皮层中tau积累之间的关系.

主要方法:

  • 分析了没有损伤的老年人 (DNA和BACS) 的tau-PET扫描 (flortaucipir).
  • 静止状态fMRI被用于为ERC和BF生成种子到voxel的FC网络.
  • 使用SUVR和voxel比例方法,在FC网络内外比较了tau-PET的吸收.

主要成果:

  • 在ERC和BF的FC网络中,与网络以外的地区相比,tau-PET的吸收率显著更高.
  • 在ERC种子中,FC和tau沉积之间的关联比BF种子更强.
  • 皮层积强度与与ERC或BF的功能连接强度显著相关.

结论:

  • 早期积区域 (如ERC和BF) 的功能连接模式预测了在皮层中的沉积.
  • 与BF相比,ERC表现出更强大的FC介导的tau差.
  • 未来的研究将研究粉样和APOE4对FC-tau传播关系的影响.