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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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阿尔茨海默氏症成像联盟

Chris Conklin1, Stefan Radonjic1, David Scott2

  • 1Clario, Inc., Philadelphia, PA, USA.

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概括
此摘要是机器生成的。

基于任务的功能磁共振成像 (tb-fMRI) 是可行的多中心试验,即使有不同的设备. 标准化培训使新手网站能够为阿尔茨海默病研究生成可分析的大脑激活数据.

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科学领域:

  • 神经成像是一种神经成像.
  • 临床试验 临床试验
  • 阿尔茨海默氏症疾病研究研究

背景情况:

  • 基于任务的功能磁共振成像 (tb-fMRI) 通过血液氧化测量大脑活动.
  • 在多中心临床试验中,标准化 tb-fMRI 设备至关重要.
  • 在TRAILBLAZER-ALZ 6研究中,研究了在早期症状性阿尔茨海默氏症 (AD) 中的多纳纳马布.

研究的目的:

  • 在一个大型的,多中心的3b期临床试验中实施和描述基于视觉任务的大脑激活.
  • 评估 tb-fMRI 在 TRAILBLAZER-ALZ 6 研究中作为探索性测量的可行性.
  • 为了评估早期有症状的阿兹海默症患者的大脑激活,确认了粉样蛋白病理.

主要方法:

  • 3台特斯拉扫描仪合格,9个站点已经建立了硬件,32个站点使用了带有投影机的de novo设置.
  • 进行了为期4分钟的视觉任务 (交替闪的圆圈和十字线).
  • 使用GRE-EPI序列获取fMRI数据,预处理,规范化,并使用异常回归的一般线性模型 (GLM) 进行分析.

主要成果:

  • 从799名参与者获得了基于任务的fMRI数据.
  • 在所有参与者中观察到显著的大脑激活 (平均T-score和BOLD对比).
  • 与新站点相比,已建立站点的参与者显示出明显更高的BOLD对比值,尽管T-score没有显著差异.

结论:

  • 基于任务的fMRI是一种可行的神经成像技术,用于多中心临床试验.
  • 新手网站可以有效地培训使用基本组件并产生可分析的tb-fMRI数据.
  • 功能性MRI设备的变化主要影响观察到的大脑激活的幅度,而不是意义.