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阿尔茨海默氏症成像联盟

Jeremy A Tanner1, Diefei Chen2, Min Soo Byun3

  • 1University of Texas Health San Antonio, San Antonio, TX, USA.

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概括
此摘要是机器生成的。

和神经退行生物标志物在美国和韩国研究中与认知最为相关. 陶氏病理学预测了美国的认知衰退,但这一发现并没有在韩国复制.

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科学领域:

  • 神经科学是一个神经科学.
  • 生物标志物 生物标志物
  • 认知科学 认知科学

背景情况:

  • 最近的阿尔茨海默病 (AD) 诊断利用了粉样蛋白 (A), (T) 和神经退行 (N) 的生物标志物.
  • 同病性血管 (V) 病理的影响和ATNV对认知的联合影响仍然不清楚.
  • 了解ATNV的作用对于个性化的AD诊断,预后和护理至关重要.

研究的目的:

  • 评估基于神经成像的ATNV测量对认知表现和下降的相对贡献.
  • 将这些贡献与跨国队列 (美国和韩国) 进行比较.

主要方法:

  • 分析了两个具有类似设计的潜在队列 (ADNI3,美国;KBASE,韩国).
  • 收集了神经影像 (PET,MRI) 和认知数据,测量了持续的ATNV预测器.
  • 多变量线性混合效应模型评估了基线ATNV和认知结果之间的关联,并对共变量进行调整.

主要成果:

  • 在两个队列中,随着临床疾病严重程度的增加,ATNV的测量量增加了.
  • 在美国队列 (ADNI) 中,tau (T) 和神经退行 (N) 与跨领域的较低认知拦截有关.
  • 陶 (T) 预测了美国的认知衰退,而血管 (V) 病理影响了特定的功能;在韩国队列 (KBASE) 中的发现有所不同.

结论:

  • (T) 和神经退行 (N) 生物标志物在美国和韩国人口中显示出与认知最强的关联.
  • 病理是美国未来认知衰退的最重要的预测因素,但在韩国队列中没有观察到这种关联.