公共卫生 公共卫生
Lauren Salminen1, Xinhui Wang2, Teresa Monreal1
1Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
微粒颗粒物 (PM2.5) 暴露与大脑变化有关,特别是健康成年人上旋环皮质厚度降低. 空气污染对大脑结构的影响因寿命和性别而异.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 放射学 放射学是一门学科.
背景情况:
- 暴露于细颗粒物 (PM2.5) 是加速大脑衰老和痴呆的已知危险因素.
- 了解PM2.5对特定大脑结构 (如皮质厚度) 的影响,对公共健康至关重要.
研究的目的:
- 在多种国际数据集中调查住宅PM2.5暴露与区域皮层厚度 (CTh) 之间的关联.
- 探索年龄和性别如何改变PM2.5暴露和CTh之间的关系.
主要方法:
- 利用了来自七个国际队伍的2,086名成年人的数据.
- 评估PM2.5暴露使用卫星估计,在MRI前三年平均.
- 采用线性混合模型来分析PM2.5和CTh之间的关联,以多个共变量进行调整,并将队列/扫描器作为随机效应.
主要成果:
- 在认知不受损的对照人群中,PM2.5暴露与上旋 (STG) 中的CTh呈反向关联.
- 在整个生命周期中观察到PM2.5对CTh的显著二次效应,在年轻,中年和老年时有不同的关联.
- 性别特定的相互作用显示,PM2.5与男性的CTh相反相关,但在几个额头区域的女性没有.
结论:
- 暴露于PM2.5与健康老年人STG中的CTh降低特别相关.
- 二级年龄-暴露相互作用表明,与空气污染相关的复杂,潜在的双相神经退行过程.
- 在PM2.5对CTh的影响中观察到的性别差异要求进一步调查与性变态和空气污染的潜在相互作用.
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