公共卫生 公共卫生
Jainjayne Daniels1, Medha Reddy1, Kaitlin Seibert1
1University of Chicago, Chicago, IL, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
前性痴呆 (FTD) 影响行为,发生在40-60岁左右. 这次审查发现FTD患病率没有显著的性别差异,尽管诊断标准和位置显示了一些差异.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 前性痴呆症 (FTD) 是一种神经退行性疾病,通常在40-60岁之间出现.
- FTD主要影响行为,认知变化不那么明显.
- 了解FTD中的性别分布对于流行病学见解至关重要.
研究的目的:
- 系统地审查和元分析女性与男性患者FTD的患病率.
- 调查诊断标准对报告FTD性别患病率的影响.
- 评估地理位置对FTD性别患病率的影响.
主要方法:
- 按照PRISMA指南进行的系统审查和元分析.
- 在Cochrane图书馆,PubMed和Embase搜索了关于FTD和性别/性别的研究.
- 包括报告FTD流行率的英语研究;不包括评论文章和病例报告.
- 利用多变量元回归的随机效应模型来分析影响因素.
主要成果:
- 总共有31项研究被纳入了元分析.
- 总的来说,在男性和女性之间没有发现FTD患病率的统计学上显著差异.
- 使用隆德-曼彻斯特标准与一般临床标准相比,观察到女性患病率更高 (p < 0.05).
- 在荷兰,FTD的女性患病率在统计上显著降低 (p < 0.05).
结论:
- 这次系统性审查和元分析发现,FTD的性别流行率没有显著差异.
- 诊断标准,特别是隆德-曼彻斯特标准,可能会影响观察到的女性患病率.
- 需要对更大的队列和确定的诊断 (病理/遗传) 进行进一步的研究,以澄清性别流行率和地理/文化因素的影响.
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