公共卫生 公共卫生
Diandra N Denier-Fields1, Maisha Islam1, Nathaniel A Chin1
1University of Wisconsin-Madison, Madison, WI, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
通过美国心脏协会的生命必需的八个 (LE8) 改善心血管健康可能会降低阿尔茨海默病 (AD) 生物标志物,如ptau217和GFAP. 这表明生活方式因素在痴呆风险中起作用.
科学领域:
- 心血管健康 心血管健康
- 神经学 神经学
- 生物标志物研究 生物标志物研究
背景情况:
- 美国心脏协会 (AHA) 的生命必不可少的八个 (LE8) 通过八个生活方式因素来评估心血管健康.
- 心血管健康不佳与认知能力下降和痴呆症有关.
- 基于血液的生物标志物是评估痴呆风险的新兴工具,包括阿尔茨海默病 (AD).
研究的目的:
- 调查LE8得分和与AD相关的并发血生物标志物之间的关联.
- 为了确定LE8测量的生活方式因素是否与特定的AD相关生物标志物相关.
主要方法:
- 分析了来自威斯康星州阿尔茨海默氏症预防注册 (WRAP) 队列的942名没有痴呆症的参与者.
- 计算LE8分数并与6个月窗口内测量的血生物标志物 (ptau217,Aβ42/40,GFAP,NfL) 相匹配.
- 根据年龄,性别和APOE进行调整的一般线性模型被用于评估关联.
主要成果:
- 较高的LE8得分 (表明更好的心血管健康) 与较低的ptau217和GFAP的度显著相关.
- 在LE8得分的每一个点的增加都与ptau217和GFAP水平的下降相关.
- 在LE8得分和Aβ42/40或NfL之间没有发现显著的关联.
结论:
- 根据LE8的定义,更好的心血管健康可能与某些与AD相关的血生物标志物水平的降低有关.
- 需要进一步的纵向研究来证实这些关联及其对认知衰退和大脑变化的影响.
- 这些发现强调了生活方式干预在痴呆症预防策略中的潜在作用.
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