公共卫生 公共卫生
Pei Huang1, Chao Gao1, Yuyan Tan1
1Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
这项研究评估了对患有轻度认知障碍 (PD-MCI) 和主观认知障碍 (PD-SCI) 的帕金森病患者的在线脑与身体康复训练 (BBRT). 这项为期3年的试验评估了BBRT在改善认知功能和数字生物标志物的有效性.
科学领域:
- 神经科学是一个神经科学.
- 数字治疗学数字治疗学
- 认知康复 认知康复 认知康复
背景情况:
- 没有有效的药理疗法可以延迟轻度认知障碍 (MCI) 到痴呆.
- 多领域的干预措施 (认知训练,运动,饮食) 是有前途的.
- 数字疗法通过各种刺激提供了增强的认知效益.
研究的目的:
- 研究在线大脑和身体康复训练 (BBRT) 在帕金森病轻度认知障碍 (PD-MCI) 患者的疗效.
- 评估BBRT在帕金森病患者的主观认知障碍 (PD-SCI) 的有效性.
- 探索非药物干预措施,以提高PD患者的认知能力.
主要方法:
- 3年,四臂随机对照试验,有260名参与者 (130名PD-MCI,130名PD-SCI).
- 55-80岁的参与者,随机分配到BBRT干预或控制 (健康教育).
- BBRT组:每周≥5次在线会议,≥15分钟/会议,远程进行36个月.
主要成果:
- 主要结果:蒙特利尔认知评估 (MOCA) 总得分.
- 二次结果:神经心理学尺度,数字生物标志物 (步态,言语,手写),血液生物标志物和神经成像 (MRI).
- 在基线,12,24和36个月的评估.
结论:
- 系统地评估BBRT-online在中国PD-MCI和PD-SCI患者的临床疗效.
- 提供关于非药物干预机制的洞察力,以提高认知功能.
- 评估BBRT对PD患者认知功能和数字生物标志物的影响.
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