公共卫生 公共卫生
Henry Brodaty1, Tiffany Chau1, Megan Heffernan2
1Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, Sydney, NSW, Australia.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
在线干预通过改善认知,心理健康和降低痴呆症风险,显著减少了老年人的认知衰退. 这种可扩展的方法对广泛的公共卫生有很大的希望.
科学领域:
- 老年学是指老年学的学科.
- 公共卫生 公共卫生
- 数字健康数字健康
背景情况:
- 多模式干预措施有望预防认知衰退,但面对面的方法在可扩展性方面是有限的.
- 在线干预为人口层面的交付提供了可扩展和可行的解决方案,但有效性仍未得到证实.
- 保持你的大脑 (MYB) 干预措施是通过在线多式联络方法开发的,以解决老年人的认知衰退问题.
研究的目的:
- 为了评估在线多式调节干预措施的有效性,保持你的大脑 (MYB),在三年内减少认知能力下降.
- 评估MYB对认知领域,心理健康和痴呆风险的影响.
- 为了确定老年人在线干预的成本效益.
主要方法:
- 从澳大利亚的45岁及以上研究中招募了14,064名55-77岁的参与者.
- 根据风险因素随机分配到个性化辅导模块 (干预) 或静态信息模块 (控制).
- 主要结果:在线全球认知分数的变化;次要结果:特定的认知领域,模块结果,痴呆风险和成本.
主要成果:
- 干预组在三年内显示出全球复合认知z-score (ES=0.18,p <0.001) 的显著改善.
- 在复杂的注意力,执行功能,学习和记忆,体力活动,营养和抑郁症 (所有p <0.001) 中观察到显著改善.
- 痴呆症风险显著降低 (p=0.007),并且发现干预措施具有成本效益,健康节省平衡.
结论:
- 在线MYB平台,根据个人风险概况量身定制,在三年内有效减少了老年人的认知衰退.
- 该干预措施是有效的,可扩展的,并可能延迟痴呆症发病,同时具有成本效益.
- 尽管证明有效,但在确保更广泛的商业或政府利益以更广泛地实施MYB干预方面仍然存在挑战.
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