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阿尔茨海默氏症成像联盟
Oriol Perera-Cruz1,2, Lídia Mulet-Pons1,2, Victor Montal3
1Department of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Barcelona, Barcelona, Spain.
皮质平均扩散度 (cMD) 捕捉了在皮质厚度 (CTh) 变化之前的衰老期间的微观结构性大脑变化,对与年龄相关的认知衰退和神经退行标志物表现出更大的敏感性.
科学领域:
- 神经成像是一种神经成像.
- 老年学是一门学科.
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 皮层厚度 (CTh) 在衰老认知中得到了很好的研究,但微观结构变化 (皮层平均扩散率 (cMD)) 了解得更少.
- cMD对临床前阿尔茨海默病 (AD) 敏感,其与健康衰老中的宏观结构,认知和生物标志物的关系尚不清楚.
研究的目的:
- 在健康成年人中研究衰老,皮质微观和宏观结构,认知和血生物标志物之间的关系.
- 为了确定cMD是否反映了比CTh更早的与年龄相关的变化.
主要方法:
- 964名健康成年人 (40-82岁) 接受了结构和扩散MRI.
- FreeSurfer计算了CTh;基于表面的方法处理了cMD.
- 分析了认知 (PACC),血生物标志物 (p-Tau181,NFL,hsCRP) 和APOE4状态.
主要成果:
- cMD和CTh都与年龄负相关,cMD变化在年轻年龄 (<50) 和CTh在老年 (>50) 时更为突出.
- 在前额区域,cMD与认知 (PACC) 和神经退行标志物 (p-Tau181,NFL) 有正相关,与炎症 (hsCRP) 有负相关.
- CTh与PACC和NFL的关联较弱;cMD和CTh的相关性因皮层区域而异.
结论:
- cMD反映了神经元密度的减少,并捕捉了衰老期间的微结构性皮质变化,可能是CTh变化之前的.
- 与CTh相比,cMD似乎对与年龄相关的认知衰退更敏感.
- 观察到的cMD,CTh和生物标志物之间的关系表明,在衰老轨迹中存在着保守的模式.
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