公共卫生 公共卫生
Andrea Z LaCroix1, Bowei Zhang1, Linda K McEvoy2
1University of California San Diego, La Jolla, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
表观遗传加快年龄测量预测女性的生存到90岁,但不区分具有或没有保存认知的女性. 需要进一步开发用于认知状态预测.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 老年学是一门学科.
- 认知科学 认知科学
背景情况:
- 表观遗传加快年龄估计器 (EAA) 预测死亡率,但没有训练长寿或保存认知.
- EAA测量的预测长期存活能力与完整的认知能力仍然在很大程度上是未知的.
研究的目的:
- 为了调查EAA测量是否预测存活到90岁与保存认知的年龄.
- 为了比较EAA的预测能力,EAA衡量了认知障碍的生存与没有认知障碍的生存.
主要方法:
- 分析了来自WHIMS队列的5293名女性,出生于1934年2月28日之前.
- 检查了14个EAA估计器,与存活到90岁时的认知能力保持,没有认知能力保持,或在90岁之前死亡有关.
- 使用多项逻辑回归,调整多个共变量,包括年龄,教育,种族和健康因素.
主要成果:
- 所有加速年龄估计都与存活到90岁的认知障碍相关.
- 关联是相同的方向和类似的大小的生存到90岁没有认知障碍.
- 估计器的主要组件 (PC) 版本显示,这两种长寿结果的关联略有强烈.
结论:
- 经过EAA的测量,老年女性的生存率持续预测到90岁.
- 在EAA测量中,没有差异性预测具有或没有完整认知的生存率.
- 这些发现支持制定EAA措施,专门培训老年人保持认知状态.
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