公共卫生 公共卫生
Julie Chandler1, Zachary Sheff1, Nalin Payakachat1
1Eli Lilly & Company, Indianapolis, IN, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
随着阿尔茨海默病 (AD) 的进展,医疗保险支出显著增加. 在临床前阿尔茨海默病的早期发现和干预对于潜在的成本节约和改善患者结果至关重要.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 卫生经济学 卫生经济学
背景情况:
- 临床前阿尔茨海默氏病 (AD) 的进展和医疗保健资源利用率 (HRU) 仍然不太清楚.
- 在无症状的AD阶段确定临床进展的早期指标至关重要.
研究的目的:
- 在具有高粉样蛋白水平的认知正常个体中描述AD进展和HRU.
- 评估AD进展标志物与医疗保健利用率和成本之间的关联.
主要方法:
- 将医疗保险索赔数据与246名参与者进行的无症状AD (A4) 抗粉样蛋白治疗研究的结果联系起来.
- 使用临床痴呆症评分表-全球分数 (CDR-GS) 和医疗保险数据 (认知障碍诊断,AD诊断,JEN脆弱指数 (JFI) ≥6) 定义了AD进展.
- 通过逻辑回归和线性回归分析了AD进展与诊断,遭遇和支付之间的关联.
主要成果:
- 38%的参与者显示CDR-GS进展; 46%的参与者被诊断为认知障碍,24%的参与者被诊断为AD,30%的参与者被诊断为JFI≥6.
- 阿尔茨海默病的进展与情绪和焦虑障碍,跌倒和更高的住院患者利用率的诊断增加有关.
- 医疗保险支付随着AD进展的认知障碍 (45%),AD诊断 (66%) 和JFI≥6 (103%) 定义而显著增加.
结论:
- 随着阿尔茨海默病从临床前阶段发展到症状阶段,医疗保险支出不断增加.
- 需要进一步的研究,以探索与延迟进展到症状AD相关的成本节约.
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