公共卫生 公共卫生
Kelley M Faber1, Cory Weinfeld2, Abigail Erickson3
1National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Indianapolis, IN, USA.
美国国家老年阿尔茨海默氏病家庭研究研究所 (NIA-AD FBS) 是全球最大的家族阿尔茨海默氏病数据库,为遗传研究提供了宝贵的数据和生物样本. 140多个出版物已经利用了这个资源,促进了对阿尔茨海默氏症遗传学的理解.
科学领域:
- 遗传学 遗传学 是一个
- 神经科学是一个神经科学.
- 生物医学研究生物医学研究
背景情况:
- 国家老年阿尔茨海默氏病家庭研究研究所 (NIA-AD FBS) 成立于2002年,是一项多站点的纵向倡议.
- 它的主要目标是为全球调查人员提供全面的数据和生物样本资源.
- 该研究旨在促进阿尔茨海默病领域的研究人员之间的合作和资源共享.
研究的目的:
- 招募阿尔茨海默病 (AD) 患病率高的家庭,包括晚发病 (LOAD) 和早期发病 (EOAD) 的家庭.
- 为了研究目的,从参与者那里收集大量的临床,遗传和生物数据.
- 促进基因研究,调查家族性阿尔茨海默病的潜在原因.
主要方法:
- 招募至少有两个受影响个体和一个愿意的一级亲属的家庭.
- 收集各种生物样本,包括DNA,血和PBMC,以及临床和认知数据.
- 在多个地点进行统一的评估,有面对面或远程评估和移动瘤手术服务的选择.
主要成果:
- 招募了1756个家庭,包括来自高加索,非洲裔美国人和西班牙裔族群的9682名家庭成员.
- 汇集了丰富的数据集,包括纵向临床数据,认知评估,家族史和各种生物样本.
- 生成的基因型数据包括APOE,GWAS,WES,WGS,大脑甲基化,RNA测序和生物标记数据.
结论:
- NIA-AD FBS代表了世界上最大的家族阿尔茨海默病研究队列.
- 这项研究的数据和样本在140多篇关于阿尔茨海默氏症遗传学的出版物中发挥了重要作用.
- 由NIA-AD FBS提供的全面资源对于促进对阿尔茨海默病的科学理解至关重要.
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