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相关概念视频

Primary Healthcare Services01:30

Primary Healthcare Services

1.9K
Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
In 1978, international leaders convened in Alma-Ata, Kazakhstan, for what would be a pivotal event in global health. The Alma-Ata Declaration was the first to call...
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Levels of Health Promotion and Illness Prevention01:26

Levels of Health Promotion and Illness Prevention

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Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
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Preventive Healthcare Services01:30

Preventive Healthcare Services

1.8K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
1.8K
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
439
Healthcare Agencies II01:17

Healthcare Agencies II

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There are various healthcare agencies in the United States—some of which are managed by religious institutions and others by different government branches.
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources,...
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Methods Of Healthcare Delivery System01:26

Methods Of Healthcare Delivery System

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At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
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公共卫生 公共卫生

Erika Walker1, Scarlet M Cockell1, Belinda L Needham1

  • 1University of Michigan, Ann Arbor, MI, USA.

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PubMed
概括
此摘要是机器生成的。

生物衰老的DNA甲基化措施与老年人的认知功能有关. 像GrimAge2这样的加速衰老标志物和较短的端粒长度与较低的认知测试分数相关.

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科学领域:

  • 老年学是指老年学的学科.
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 认知神经科学 认知神经科学

背景情况:

  • 通过DNA甲基化评估的生物衰老,显示出作为认知健康的生物标志物具有前途.
  • 以前的研究表明,衰老标志物与认知结果之间存在联系.

研究的目的:

  • 研究基于DNA甲基化的衰老措施与60岁及以上成年人认知功能之间的关联.
  • 利用国家健康和营养检查调查 (NHANES) 的数据进行全国代表性的分析.

主要方法:

  • 综合NHANES数据 (1999-2002) 包括DNA甲基化和认知测试.
  • 从全基因组DNA甲基化数据开发了13种生物衰老措施.
  • 使用数字符号替代测试 (DSST) 评估认知;轻度认知障碍定义为DSST得分低于25百分位.
  • 采用加权线性回归和修改的Poisson模型,对共变量进行调整,并使用错误发现率控制多重比较.

主要成果:

  • 在13项DNA甲基化衰老测量中,10项与DSST得分有显著关联 (调整后p <0.05).
  • 一年加快衰老 (GrimAge2) 与DSST得分下降0.41个点相关 (p=0.001).
  • 端粒长度下降1个标准偏差与DSST得分下降2.19个点有关 (p=0.001).
  • 在男性和非西班牙裔白人参与者中发现了更强烈的关联.
  • 在调整后,DNA甲基化测量和轻度认知障碍之间没有发现显著的关联.

结论:

  • 基于DNA甲基化的生物衰老指标与老年人的认知表现有关.
  • 这些发现表明,DNA甲基化可以作为一种有价值的生物标志物,用于评估老年人群的认知状态.