公共卫生 公共卫生
Yi Chen1, Annie Chen2, Melinda C Power2
1Rush Alzheimer's Disease Center, Chicago, IL, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
痴呆症的诊断往往是延迟的. 阿尔茨海默病 (AD) 和临主导的与年龄相关的TDP-43脑病变神经病变 (LATE-NC) 病理与更及时的诊断有关,而血管和莱维体病理则不是.
科学领域:
- 神经病理学神经病理学
- 痴呆症的诊断 痴呆症的诊断
- 临床结果 临床结果
背景情况:
- 痴呆症诊断经常延迟,可能会阻碍及时治疗和支持.
- 特定的大脑病理与痴呆症诊断的及时性之间的关联仍然不清楚.
- 了解这些关联对于改善痴呆症护理途径至关重要.
研究的目的:
- 研究特定神经病理和痴呆症诊断的及时性之间的关系.
- 为了确定阿尔茨海默病 (AD),LATE-NC,血管或莱维体病理是否影响诊断延迟.
- 为了确定影响痴呆症诊断及时性的因素,在医疗保健机构.
主要方法:
- 利用了来自拉什阿尔茨海默病中心的五个队伍,与相关的医疗保险数据和死后尸检联系在一起.
- 确定的神经病理包括AD,LATE-NC,血管和莱维体 (LB).
- 基于医疗保险索赔相对于队列痴呆发病的定义及时诊断;逻辑回归评估了病理学关联.
主要成果:
- 在548名参与者中,只有54%的人得到了及时的痴呆症诊断.
- 阿尔茨海默病 (AD) 和LATE-NC病理独立地与及时诊断的更高可能性相关 (分别为OR=1.91和OR=1.83).
- 血管和莱维体 (LB) 病理与及时诊断没有显著的关联.
结论:
- 患有AD和LATE-NC病理的个体被及时诊断的可能性是两倍.
- 在AD/LATE-NC病例中及时诊断的原因可能来自不同的临床表现.
- 缺乏血管病理的关联凸显了在识别与血管健康相关的认知障碍方面的潜在差距.
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