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阿尔茨海默氏症成像联盟

Rafael V Lippert1,2, A Zarina Kraal1,3, Natalie C Edwards1,2

  • 1Columbia University Irving Medical Center, New York, NY, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
概括
此摘要是机器生成的。

阿尔茨海默病 (AD) 的遗传风险与脑血管疾病和神经退行症标志物有关. 白质过强度调解了这种关联,即使没有粉样蛋白存在,也会影响认知.

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科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 是一个遗传学.
  • 老年学是一门学科.

背景情况:

  • 脑血管疾病 (CVD),炎症和神经退行是已知的阿尔茨海默病 (AD) 的危险因素.
  • 了解遗传倾向与这些病理因素之间的相互作用,对于阐明AD的发病性至关重要.
  • 这项研究调查了AD的遗传风险与CVD标志物,炎症和神经退行症在认知不受损的个体之间的关联.

研究的目的:

  • 检查年龄定多基因风险评分 (CIR) 与脑血管负担,炎症和神经退行症标志物的关联.
  • 确定这些因素是否调解遗传风险和认知功能之间的关系.
  • 探索这些由粉样β (Aβ) 阳性分层的关联.

主要方法:

  • 利用了阿尔茨海默病神经成像计划 (ADNI) 的601名无损参与者的数据.
  • 评估的白质超强度 (WMH) 量,CIR得分,血GFAP和NfL度以及认知表现.
  • 使用线性模型进行关联分析和调解分析,以测试WMH和生物标志物的作用.

主要成果:

  • 较高的CIR得分与增加的WMH体积,NfL和GFAP度相关.
  • CIR与较低的执行功能,记忆和语言得分有关.
  • 显著地介绍了CIR和认知领域之间的关系;NfL也介绍了执行功能.

结论:

  • 在没有认知障碍的老年人中,AD的遗传风险增加与更大的脑血管负担和神经退行症标志物有关.
  • 白质过强度在将遗传阿尔茨海默病风险与认知能力下降联系起来方面起着调解作用,不论粉样蛋白状况如何.
  • 这些发现强调了脑血管疾病对患上临床阿尔茨海默病的遗传风险的重大贡献.