公共卫生 公共卫生
Alberto R Ramos1, Wassim Tarraf2, Charles Decarli3,4
1University of Miami Miller School of Medicine, Miami, FL, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
老年人睡眠时间较长 (9+小时) 与14年内认知能力下降的加快有关. 无论睡眠呼吸暂停的严重程度如何,这种联系都会持续下去,强调健康的睡眠时间对大脑健康有益.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 睡眠医学 睡眠医学
背景情况:
- 睡眠对老年人的认知健康至关重要,之前的研究将长时间睡眠时间与神经认知能力下降联系起来.
- 这种关联随着时间的推移而持久,以及其通过睡眠呼吸暂停严重程度的潜在调节仍然不清楚.
研究的目的:
- 为了研究基线睡眠时间和14年的认知轨迹之间的长期关联.
- 为了确定睡眠呼吸暂停的严重程度是否影响睡眠时间和认知能力下降之间的关系.
主要方法:
- 对来自西班牙裔社区健康研究/拉丁裔研究 (HCHS/SOL) 的2521名参与者的分析,使用基线睡眠数据.
- 利用多层线性模型来评估基于基线睡眠时间 (<7,7-9,9+小时) 和睡眠呼吸暂停严重程度 (REI <15对15+) 的认知变化轨迹.
- 对人口因素和APOE4基因型进行控制.
主要成果:
- 在基线报告9个小时或更长时间睡眠的个体在14年的随访期间表现出更快的认知衰退率.
- 长时间睡眠时间和认知能力下降之间的关联没有受到睡眠呼吸暂停的严重程度的显著改变.
- 平均睡眠时间为7.8小时,平均REI为7.5.
结论:
- 长时间的起始睡眠时间与老年成人14年的加速认知衰退有关.
- 睡眠呼吸暂停的严重程度似乎没有改变这种关系.
- 建议促进健康的睡眠时间,以支持大脑健康和减轻认知能力下降.
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