公共卫生 公共卫生
Robrielle M Pierce1, Kiana A Scambray1, Monica E Walters1
1University of Michigan, Ann Arbor, MI, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
种族歧视,特别是重大生活事件,与老年黑人成年人通过增加白质超强度 (WMH) 的认知衰退有关. 解决歧视问题可能会改善认知健康公平.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 老年学是指老年学的学科.
背景情况:
- 种族歧视与较差的认知健康有关,其潜在机制尚不清楚.
- 白质超强度 (WMH) 与歧视有关,并可能调解认知效应.
- 了解这些联系对于改善老龄化人口的认知健康平等至关重要.
研究的目的:
- 调查WMH是否调解了黑人老年人种族歧视和认知功能之间的关联.
- 检查种族歧视与主观记忆,客观情节性记忆和客观执行功能之间的关系.
- 探索WMH在从歧视到认知结果的途径中的作用.
主要方法:
- 351名非拉丁裔黑人参与者 (55岁以上) 没有痴呆症的横截面研究.
- 使用日常歧视和终身歧视尺度的主要经验来评估种族歧视.
- 测量主观记忆,客观情节性记忆和执行功能;从脑部成像中量化WMH.
主要成果:
- 终身种族歧视与更差的执行功能和更大的主观记忆问题相关.
- 终身种族歧视与WMH增加有关,这反过来又与较差的客观记忆和执行功能有关.
- WMH调解了终身种族歧视对客观记忆和执行功能的影响.
结论:
- 白质超强度 (WMH) 是将种族歧视与认知障碍联系起来的关键机制.
- 涉及种族歧视的主要生活事件显著影响客观认知功能,建议针对性干预.
- 解决基于种族的歧视的政策对于减少WMH负担和提高老年黑人成年人的认知健康至关重要.
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