公共卫生 公共卫生
Sophie Lefèvre-Arbogast1,2,3, Pierre Scala4, Aurore Zorilla5
1Bordeaux Population Health Research Center, Inserm U1219, University of Bordeaux, Bordeaux, NA, France.
低水平暴露于PCB和OCP等持久有机污染物 (POP) 并没有显著增加老年人痴呆风险. 然而,APOE-ɛ4载体显示出特定的高化PCB的不良影响.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
背景情况:
- 持久性有机污染物 (POP),包括多二 (PCB) 和有机农药 (OCP),是已知的神经毒剂.
- 低级环境POP暴露对大脑衰老病理的影响在一般人群中仍然不清楚.
研究的目的:
- 评估血POP度与老年人痴呆相关结果之间的潜在关联.
- 研究POPs,认知功能和中间叶 (MTL) 体积之间的关系.
主要方法:
- 利用了法国三城市研究中的515名参与者的数据,分别在17年和10年内重复认知评估和神经成像.
- 测量了12种OCP和15种PCB的血度;获得了POP分数.
- 使用考克斯和线性混合模型分析了与痴呆风险,认知衰退和MTL缩的关联,并对共变量进行调整.
主要成果:
- 在整体POP暴露 (个体POP或POP得分) 和痴呆风险,认知衰退或MTL缩之间没有发现显著的关联.
- 观察到APOE基因型和高化PCB (180,194,196-203) 之间存在显著的相互作用.
- 暴露于特定PCB的APOE-ɛ4载体显示出痴呆症风险增加和认知衰退/MTL缩加速,而非载体显示出相反的趋势.
结论:
- 这项研究没有找到强有力的证据,表明低级环境POP暴露与老年人群中痴呆,认知衰退或大脑缩的风险增加有关.
- 然而,APOE-ɛ4载体可能更容易受到某些高含量PCB的有害神经影响.
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