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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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阿尔茨海默氏症成像联盟

Taylor W Schmitz1

  • 1Schulich Medicine and Dentistry, London, ON, Canada; Robarts Research Institute, London, ON, Canada.

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概括
此摘要是机器生成的。

使用触摸屏连续性能任务 (CPT) 的跨物种认知测试有助于阿尔茨海默病 (AD) 研究. 这种方法将遗传风险,认知表现和神经生物学联系在一起,以了解早期AD机制.

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科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 是一个遗传学.
  • 认知科学 认知科学

背景情况:

  • 跨物种认知测试促进了阿尔茨海默病 (AD) 的理解.
  • 鼠标模型提供了对影响认知衰退的遗传和生物因素的因果洞察.
  • 触摸屏的认知任务通过实现一致的人类和小鼠测试来弥合临床前和临床研究.

研究的目的:

  • 在AD小鼠模型和患AD风险的人类并行研究中整合同源的触摸屏认知测试.
  • 探索遗传因素 (粉样蛋白,,ApoE基因型) 如何与执行职能中的年龄和性别相互作用,使用持续性能任务 (CPT).
  • 与标准神经心理测试相比,研究触摸屏认知测试对早期AD相关衰退的敏感性.

主要方法:

  • 使用同类触摸屏测试,包括CPT,在下一代AD小鼠模型和患AD风险的人类中.
  • 采用带有人性化敲进基因 (粉样蛋白,,ApoE ε3/ε4) 的小鼠模型来研究与年龄和性别的遗传相互作用.
  • 将CPT整合到纵向PREVENT-AD研究中,收集了来自425多名具有完整认知能力和AD家族病史的人的数据.

主要成果:

  • CPT已被整合到PREVENT-AD研究中,从220多名个人中获取数据.
  • 从PREVENT-AD队列中从大约80名参与者收集了纵向CPT数据.
  • 这项研究利用了包括神经成像,生物标志物和从PREVENT-AD队列的认知评估在内的综合数据集.

结论:

  • 人类和小鼠的基于触摸屏的认知测试阐明了AD风险机制.
  • PREVENT-AD人类和小鼠的CPT数据可以揭示早期认知功能障碍中ApoE基因型,年龄和性别之间的相互作用.
  • 在大型联盟中扩大触摸屏测试将将遗传风险,认知表现和神经生物学标记联系起来,以推进AD的理解和干预.