公共卫生 公共卫生
Diandra N Denier-Fields1, Ruocheng Dong1, Briana L Rocha1
1University of Wisconsin-Madison, Madison, WI, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
地中海-DASH干预神经退行性延迟 (MIND) 饮食与与阿尔茨海默病 (AD) 和神经退行性生物标志物相关的特定血代谢物有关. 这些发现表明饮食通过代谢途径影响痴呆风险.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 像ptau217,Aβ42/40,GFAP和NfL这样的等离子体生物标志物表明阿尔茨海默病 (AD),神经炎症和神经退行.
- MIND饮食是一种生活方式因素,与降低痴呆风险有关.
- 血代谢学提供了对饮食影响的客观测量,补充了传统的问卷.
研究的目的:
- 研究MIND饮食得分,血代谢物和AD和神经退行症的关键血生物标志物之间的关联.
- 确定与MIND饮食相关的特定血代谢物及其与痴呆症生物标志物的关系.
主要方法:
- 利用了来自威斯康星州阿尔茨海默氏症预防注册 (WRAP) 队列中的1,104名认知无障碍参与者的数据.
- 确定了72种与MIND饮食得分相关的血代谢物.
- 应用主要成分分析 (PCA) 对代谢物数据和一般线性回归来评估与血生物标志物 (ptau217,Aβ42/40,GFAP,NfL) 的关联,根据年龄,性别和APOE进行调整.
主要成果:
- 四个主要成分 (PC) 解释了MIND饮食相关代谢物的38%变异.
- 在代谢物PC和血生物标志物之间发现了显著的积极关联:PC1与ptau217和NfL;PC2与GFAP和NfL;PC3与所有四个生物标志物;PC4与ptau217.
结论:
- 与MIND饮食相关的血代谢物组与AD和神经退行症的生物标志物相关.
- 这些代谢物组包括必需氨基酸,欧米茄-3脂肪酸,植物/肠道微生物衍生的代谢物和脂.
- 饮食干预可以调节与痴呆症生物标志物相关的代谢途径.
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