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阿尔茨海默氏症成像联盟

Yuta Katsumi1, Ryan Eckbo1, Michael Brickhouse2

  • 1Frontotemporal Disorders Unit and Massachusetts Alzheimer's Disease Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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概括

早期发病的阿尔茨海默病 (EOAD) 破坏了大脑网络连接,在受影响的区域显示出更强的连接. 这种超连接性与EOAD患者的认知衰退和大脑缩有关.

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科学领域:

  • 神经科学是一个神经科学.
  • 医疗成像医学成像
  • 神经学 神经学

背景情况:

  • 零星早期发病的阿尔茨海默氏病 (EOAD) 涉及神经退行,主要发生在后 temporoparietal 区域.
  • 这些区域是主要大脑网络中的关键节点,包括默认模式,前端对立体,语言和背部注意力网络.
  • 之前关于EOAD功能连接性的研究使用了小样本,产生了不一致的结果.

研究的目的:

  • 在一大群零星的EOAD患者中调查大脑网络功能完整性的破坏.
  • 为了确定EOAD中功能连接的改变是否与认知障碍和皮质缩有关.

主要方法:

  • 分析了来自239名零星EOAD患者和68名认知不受损 (CU) 控制者的全脑功能MRI数据,这些数据来自长度早期阿尔茨海默病研究 (LEADS).
  • 预处理和MRI数据的质量控制,然后在确定的EOAD签名区域内进行基于种子的功能连接性分析.
  • 在EOAD和CU组之间对功能连接图进行比较,控制年龄,性别和头部运动.

主要成果:

  • 与CU参与者相比,EOAD患者在EOAD签名区域内表现出明显更强的功能连接,影响多个大规模网络.
  • 在EOAD患者中,这些网络内的功能连接性增加与更大的认知障碍和皮质缩有关.
  • 探索性分析揭示了与AD相关的突出超连接性,涉及默认模式和前对对联网络.

结论:

  • 散发性EOAD的特点是,在脆弱的皮质区域内,内在功能连接的显著破坏.
  • 这些发现凸显了EOAD中皮质功能网络的选择性脆弱性.
  • 观察到的连接性改变可能会解释这种阿尔茨海默氏症现象型中不同的病理模式和认知缺陷.