公共卫生 公共卫生
Jennifer A Deal1, James Russell Pike2, Vidyulata Kamath3
1Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
老年人听力损失与NfL等神经退行性标志物有关,但与阿尔茨海默氏症特异性粉样蛋白或蛋白无关. 这表明听力和痴呆的途径可能与核心阿尔茨海默氏症变化分开.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 听力学 听力学是指听力学.
背景情况:
- 听力损失是阿尔茨海默病和相关痴呆症 (ADRD) 的已知危险因素.
- 连接听力损失和ADRD的潜在机制仍然不清楚.
- 这项研究探讨了听力损失和ADRD等离子体生物标志物之间的关系.
研究的目的:
- 为了研究听力损失和ADRD的血生物标志物之间的横截面关联.
- 为了确定听力损失是否与更广泛的神经退行症标志物或AD特异性标志物相关.
- 假设潜在的机制链接听力和ADRD.
主要方法:
- 利用了来自社区神经认知研究 (ARIC-NCS) 动脉样硬化风险的数据.
- 测量了纯色调空气导电听力值,并模拟了更好的耳朵听力损失.
- 使用Quanterix SiMoA平台分析了等离子体生物标志物,包括粉样蛋白-β 42/40比率,p-tau 181,NfL和GFAP.
- 采用多变量调整线性回归,控制众多的人口,临床和生活方式因素.
主要成果:
- 听力损失与AD特定的生物标志物没有相关性 (粉样蛋白-β 42/40比,p-tau 181).
- 听力损失与一般神经退行症标志物 (NfL和GFAP) 的相关性较弱.
- 在调整后的模型中,每增加10dB的听力损失都与日志NfL增加0.079 (95%CI:0.007,0.150) 相关.
结论:
- 老年人听力较差与神经退行症的血生物标志物有关,特别是NfL.
- 这种关联独立于AD特异性标记物,如粉样蛋白和蛋白.
- 研究结果表明,连接听力和ADRD的途径可能与与阿尔茨海默氏症相关的核心脑病理学不同.
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