公共卫生 公共卫生
Alexa S Gonzalez1, Andrea P Ochoa Lopez1, Stephanie Torres2
1University of Houston, Houston, TX, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
墨西哥裔美国人痴呆症诺莫格拉姆 (MADeN) 评分有效预测西班牙裔/拉丁美洲裔和黑人个体的痴呆风险和认知衰退. 对主观记忆的担忧为非西班牙裔白人提供了额外的见解.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 痴呆症风险评分有助于早期识别阿尔茨海默病和相关痴呆症 (ADRD).
- 现有的风险评分可能在不同人群中具有较低的预测能力,因为缺乏种族/种族考虑因素.
- 墨西哥裔美国人痴呆症诺莫格拉姆 (MADeN) 评分是为了评估痴呆症风险而开发的.
研究的目的:
- 评估墨西哥裔美国人痴呆症名录 (MADeN) 评分与主观和客观认知的关联.
- 评估MADeN得分在各种种族群体的预测效用,包括西班牙裔/拉丁裔美国人 (H/L),非西班牙裔黑人和非西班牙裔白人.
主要方法:
- 利用了3634名健康和衰老大脑研究参与者的数据:健康差异.
- 根据年龄,教育,社会支持和健康状况等因素计算了修改后的MADeN分数.
- 采用嵌套回归模型来检查MADeN得分,主观记忆问题 (SMC) 和认知表现之间的关系,按种族/种族分层.
主要成果:
- 修改后的MADeN评分解释了全样本中SMC的15.1%的差异和认知表现的9.2%.
- 在H/L (13.3%),黑人 (5.2%) 和白人 (2.3%) 个体中,MADeN得分显示出对认知表现的显著预测能力.
- SMCs解释了黑人和白人个体的额外认知差异,但不是H / Ls.
结论:
- 较高的MADeN分数与主观记忆问题增加和认知表现较差相关.
- 在H/L个体中,MADeN评分对风险检测最有效,而在黑人个体中则具有中等意义.
- 对主观记忆的关注为非西班牙裔白人个人提供了对认知表现的更有信息的见解.
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