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阿尔茨海默氏症成像联盟

Arunima Kapoor1, Shubir Dutt2,3, John Paul M Alitin1

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概括
此摘要是机器生成的。

较高的脑血管反应率 (CVR) 显著降低了周血管空间扩大 (ePVS) 和白质超强度 (WMH) 的风险. 心血管回路逆差可能表明早期变化导致这些大脑小血管疾病病理.

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科学领域:

  • 神经学 神经学
  • 神经成像是一种神经成像.
  • 脑血管疾病研究研究

背景情况:

  • 扩大周血管空间 (ePVS) 和白质强度过高 (WMH) 是大脑小血管疾病的常见并发指标.
  • 脑血管功能障碍对ePVS和WMH的影响尚未得到充分研究.
  • 大脑血管活性 (CVR) 是大脑血管功能的动态标志物.

研究的目的:

  • 调查没有ePVS/WMH,只有ePVS,只有WMH,以及ePVS和WMH的个体之间的CVR差异.
  • 为了确定大脑血管功能受损是否会增加这些病理的风险.
  • 评估CVR作为大脑小血管疾病的潜在早期标志物.

主要方法:

  • 招募了118名非痴呆症,非中风的老年人 (平均年龄68.4岁).
  • 使用伪连续动脉旋转标记 (pCASL) MRI 来量化高头症期间的全脑CVR.
  • 在中心半形 (CS) 和WMH中得分的ePVS使用Fazekas尺度.

主要成果:

  • 在四组中观察到CVR的显著差异 (p=.021).
  • 与没有任何病理的患者相比,患有ePVS和WMH的个体表现出较低的CVR.
  • 较高的CVR与联合ePVS和WMH的风险降低有关 (OR=0.78,p=.035),即使调整了年龄和性别.

结论:

  • 升高的CVR与发展联合WMH和ePVS-CS.的风险明显降低.
  • CVR 缺陷可能代表大脑小血管疾病的早期病理变化.
  • 未来的研究应该探索区域CVR差异及其对认知的长期影响.