Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

251
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
251
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

212
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
212
Brain Imaging01:14

Brain Imaging

629
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
629
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

460
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
460
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

758
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
758

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Volumetric postmortem MRI of the medial temporal lobe in Alzheimer's disease and related disorders: methodological advances and implications for in vivo biomarker development.

NeuroImage·2026
Same author

Cortical gray-white matter contrast alterations precede amyloid-β positivity and macrostructural changes in older adults without dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Attention Networks Connectivity After Cognitive Rehabilitation in Alzheimer's Disease.

Journal of geriatric psychiatry and neurology·2026
Same author

Multivariate age-related variations in quantitative MRI maps: widespread age-related differences revisited.

Frontiers in neuroscience·2026
Same author

Toward a spatiotemporal neurocognitive framework of manipulable object processing.

Neuroscience and biobehavioral reviews·2026
Same author

Sleep arousals are associated with the polygenic risk for developing Alzheimer's disease and with cognitive change in healthy late middle-aged individuals.

Sleep·2026

相关实验视频

Updated: Jan 8, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

751

阿尔茨海默氏症成像联盟

Lara Huyghe1, Lisa Quenon1,2, Jean-Louis Bayart3,4

  • 1Institute of Neuroscience, UCLouvain, Brussels, Belgium.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
概括
此摘要是机器生成的。

血p-tau217和认知测试显示,在未受损的个体中早期检测阿尔茨海默病 (AD) 是有前途的. 将这些标记物结合起来,可以显著提高识别临床前AD病理的准确性.

更多相关视频

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.0K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

40.8K

相关实验视频

Last Updated: Jan 8, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

751
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.0K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

40.8K

科学领域:

  • 神经科学是一个神经科学.
  • 生物标志物 生物标志物
  • 神经成像是一种神经成像.

背景情况:

  • 阿尔茨海默病 (AD) 诊断依赖于昂贵的粉样蛋白 (Aβ) 和tau-PET成像,限制其用于查无损人口的使用.
  • 研究重点是用于检测预症状AD病理的经济实惠的方法,包括认知指标和血液生物标志物,如可溶性化 (p-tau).
  • 对这些新兴标记物的对比比较和它们对早期AD检测的附加值很少.

研究的目的:

  • 调查血p-tau217和认知任务在识别临床无障碍 (CU) 个体与阿兹海默症病理的PET成像证据的实用性.
  • 为了比较血p-tau217的诊断准确性和用于早期发现AD的特定认知测试.
  • 评估结合血生物标志物和认知措施用于早期AD检测的附加值.

主要方法:

  • 80名CU老年人接受了血p-tau217测试,Aβ-PET和tau-PET扫描,以及神经心理评估,包括概念匹配任务 (CMT) 和视觉短期记忆绑定测试 (VSTMBT).
  • 参与者根据粉胺-PET (Aβ-或Aβ+) 或tau-PET (Tau-CU或Tau+CU) 状态进行分类.
  • 用接收器操作特征 (ROC) 曲线来确定单个和组合标记器在区分PET阳性和PET阴性个体中的准确性.

主要成果:

  • 血p-tau217在检测初始的氨基粉症或陶病症方面表现出最高的准确性 (AUC=0.91).
  • VSTMBT是检测Aβ (AUC=0.722) 和tau-PET阳性 (AUC=0.743) 的最敏感的认知指标.
  • 结合血p-tau217和认知标志物,实现了高精度 (AUC=0.93对于Aβ,AUC=0.95对于tau) 和提高了检测tau-PET阳性的灵敏度至1.0.

结论:

  • 血生物标志物和认知措施的组合显示出对早期诊断阿尔茨海默病的重大前景.
  • 这种综合方法提高了在临床上没有损害的个体中识别临床前AD病理的能力.
  • 进一步验证这些综合标记物的研究可能会导致更容易获得的AD查工具.