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阿尔茨海默氏症成像联盟

Md Tahmid Yasar1, Grant Nikseresht1, Abdur Raquib Ridwan2

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此摘要是机器生成的。

在体内检测到的脑微出血 (CMB) 在死后持续存在,并且在体外MRI上可见. 较高的CMB计数与认知能力下降和大脑粉样血管病变 (CAA) 相相关.

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科学领域:

  • 神经成像是一种神经成像.
  • 神经病理学神经病理学
  • 老年学是一门学科.

背景情况:

  • 大脑微出血 (CMB) 是老年人常见的小出血.
  • 脑脊髓炎与认知能力下降,大脑体积减少以及中风和死亡风险增加有关.
  • 这项研究使用体内和体外MRI研究了CMB,将发现与临床和病理数据相关联.

研究的目的:

  • 通过体内和体外MRI检测大脑微型血流 (CMB) 的持久性和检测能力.
  • 评估CMB和临床评估之间的关联,包括认知功能.
  • 检查CMBs和神经病理学之间的关系,例如大脑粉样血管病变 (CAA).

主要方法:

  • 一项对37名社区老年人的纵向研究包括年度认知测试和3TMRI (3D-T1w MPRAGE和ME-GRE).
  • 尸检后,体外MRI (3D ME-SE和ME-GRE) 在一个大脑半球上进行.
  • 神经病理学评估包括脑血管病理;CMB在体内和体外MRI上进行了注释,以进行比较.

主要成果:

  • 59%的参与者在体外MRI上至少有一个CMB;65%的参与者在体内和体外CMB之间显示了完全匹配.
  • 在所有不匹配的情况下,ex vivo CMB 数量高于 in vivo 数量.
  • 活体CMB数量的增加与较长的死前间隔,较大的认知障碍和CAA的存在相关.

结论:

  • 在生命期间观察到的大脑微型血流 (CMB) 在大脑中持续存在,并且可以在体外MRI上检测到.
  • 在经历认知障碍和脑粉样血管病变 (CAA) 的个体中,CMB的数量随着时间的推移而增加.
  • 这项研究验证了CMB检测方法,并突出了它们在老化大脑中的进展.