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阿尔茨海默氏症成像联盟

Prithvi Arunachalam1, Francesca Treves1,2, Leonard Pieperhoff1

  • 1Amsterdam University Medical Center (Amsterdam UMC), Amsterdam, North Holland, Netherlands.

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概括
此摘要是机器生成的。

大脑结构和功能合因年龄,性别和老年人粉样蛋白水平而异. 较高的粉样蛋白负担和年龄与脱的增加有关,而性别表现出差异性影响,影响老化和早期阿尔茨海默病 (AD) 中的大脑网络分析.

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科学领域:

  • 神经科学是一个神经科学.
  • 脑部成像 脑部成像
  • 网络分析 网络分析

背景情况:

  • 大脑功能依赖于神经通信的结构途径.
  • 大脑结构和功能 (合) 之间的关系因区域而异,并且在衰老和早期阿尔茨海默病 (AD) 中发生变化.
  • 这项研究调查了年龄,性别和粉样蛋白负担如何影响非痴呆老年人的结构功能合.

研究的目的:

  • 检查年龄,性别和粉样蛋白负担与结构功能合的关联.
  • 为了确定结构功能合的区域差异.
  • 了解这些因素对大脑网络完整性的影响,在衰老和AD的背景下.

主要方法:

  • 从439名参与者中利用扩散权重成像 (DWI),功能磁共振成像 (fMRI) 和粉样正子辐射断层扫描 (PET).
  • 使用图形信号处理框架计算了结构脱指数 (SDI),以量化大脑结构功能脱.
  • 采用线性模型来评估年龄,性别和粉样蛋白负担对全球,网络和区域SDI的影响.

主要成果:

  • 年龄与体力运动网络中SDI增加有关;较高的粉样蛋白负担与全球和网络水平SDI增加相关,特别是在时间区域.
  • 男性的全球和网络层面的SDI较低,前部区域的区域差异较大.
  • 粉样蛋白负担显示,在多个大脑网络和区域中,与较高的SDI有显著的关联.

结论:

  • 年龄,性别和粉样蛋白负担独立地影响不同大脑尺度的结构功能合.
  • 多模式大脑网络分析对检测与衰老和早期AD病理生理学相关的变化敏感.
  • 这些发现突出了与衰老,性别和粉样蛋白沉积相关的明显的病理生理过程.