Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

251
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
251
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

212
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
212
Brain Imaging01:14

Brain Imaging

629
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
629
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

460
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
460
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

758
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
758

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Cellular heterogeneity of hepatic granuloma formation and evolution in murine schistosomiasis japonica.

Nature communications·2026
Same author

Albumin-Bound Paclitaxel (SYHX2011) in Patients with Advanced Breast Cancer: A Multicenter, Randomized, Double-Blind, Phase III Study.

Cancer communications (London, England)·2026
Same author

Can the All of Us sample be reweighted to mirror a nationally representative sample? A comparison of mortality predictors.

Epidemiology (Cambridge, Mass.)·2026
Same author

Gapless and phased genome assembly reveals post-allopolyploidization subgenomic diversification of tobacco centromeres.

Genome biology·2026
Same author

Depressive symptoms and neuroimaging markers of brain aging in an ethno-racially diverse sample: a Bayesian analysis.

American journal of epidemiology·2026
Same author

Mechanism of structural remodeling of cell-wall polysaccharides in peach during osmotic dehydration: a comparative investigation of sucrose, maltitol and their synergistic mixture.

International journal of biological macromolecules·2026

相关实验视频

Updated: Jan 8, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

751

阿尔茨海默氏症成像联盟

Sarah F Ackley1, Michael Flanders1, Ruijia Chen2

  • 1Brown University, Providence, RI, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
概括
此摘要是机器生成的。

分析阿尔茨海默病药物试验数据揭示了粉样蛋白减少.

更多相关视频

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.0K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

40.8K

相关实验视频

Last Updated: Jan 8, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

751
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.0K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

40.8K

科学领域:

  • 神经科学是一个神经科学.
  • 临床试验 临床试验
  • 生物统计学 生物统计学

背景情况:

  • 粉样蛋白去除是阿尔茨海默病 (AD) 药物试验的替代结果.
  • 对阿尔茨海默病的药物批准利用了基于粉样蛋白去除的加速批准计划.
  • 从抗粉样蛋白试验获得个人级别数据的访问是有限的,阻碍了替代品结果的验证.

研究的目的:

  • 证明流行病学和计量经济学方法的实用性,以验证在阿尔茨海默氏症药物试验中作为替代结果的粉胺.
  • 分析粉样蛋白去除对认知衰退的影响,使用来自solanezumab的A4试验的个体级数据.
  • 评估粉样蛋白减少对认知变化的因果关系,以及粉样蛋白调解药物效应的程度.

主要方法:

  • 利用了来自A4试验 (阿尔茨海默氏症临床试验联盟A4/LEARN) 815名参与者的个人数据.
  • 通过临床痴呆症评分表-盒子总和 (CDR-SB) 评分轨迹在4.5年内估计的认知变化.
  • 采用仪器变量 (IV) 方法和因果调解分析来评估粉样蛋白减少对认知的因果影响,并根据相关的共变量进行调整.

主要成果:

  • 索拉尼祖马布显示出最小的粉样蛋白减少 (-0.05SUVr) 和认知变化 (0.002CDR-SB点/月).
  • 没有观察到粉样蛋白对认知的显著非线性影响.
  • 静脉注射分析表明,粉样蛋白减少对认知变化有不确切的影响 (95% CI: -0.096,0.014).
  • 调解分析表明,粉样蛋白变化调解了索拉尼祖马布认知效果的23%,具有广泛的置信区间 (-125%,253%).

结论:

  • 应用到个体级数据的流行病学和经济学方法可以提高对粉样蛋白作为阿尔茨海默病认知替代结果的理解.
  • 由于solanezumab对粉样蛋白清除效果有限,A4试验的结果不准确.
  • 将这些分析与更有效的抗粉样蛋白疗法的数据复制,对于完善治疗策略和为药物批准中未来的替代结果使用提供信息至关重要.