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阿尔茨海默氏症成像联盟

Firoza Z Lussier1, Guilherme Povala1, Guilherme Bauer-Negrini1

  • 1University of Pittsburgh, Pittsburgh, PA, USA.

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概括
此摘要是机器生成的。

这项HEAD研究正在生成一个独特的tau-PET标记物的数据集 (MK-6240,Flortaucipir,RO948,PI-2620) 以标准化阿尔茨海默病的量化. 这种对比的目的是协调结果并指导未来的临床试验.

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科学领域:

  • 神经成像是一种神经成像.
  • 生物标志物发现发现
  • 阿尔茨海默氏症疾病研究研究

背景情况:

  • 在体内定量病理的标准化对于阿尔茨海默病 (AD) 研究至关重要,但由于-PET 标志物变异性而受到挑战.
  • 启动HEAD研究是为了解决这个问题,通过创建一个全面的,纵向的头对头数据集,多个tau-PET标记器.

研究的目的:

  • 为了协调不同tau-PET标记物的结果,包括MK-6240,Flortaucipipr,RO948和PI-2620.
  • 开发工具,在各种研究和临床试验中概括发现.
  • 提供HEAD研究数据生成进展的最新情况.

主要方法:

  • 一项涉及9个表演场所的多中心研究,旨在招募620名不同年龄组和认知状态的参与者 (年轻人,认知正常,轻度认知障碍,痴呆症).
  • 标准化临床评估,采集血液用于生物标志物储存,MRI采集和粉样蛋白-PET扫描.
  • 头对头的tau-PET成像,每个参与者至少有两个标记器,使用统一的数据处理协议.

主要成果:

  • 在26个月的时间里,注册了679名参与者,超过了9.5%的目标.
  • 数据收集正在取得进展,81%的注册参与者完成了最初的时间点,并获得了1489次头对头tau-PET扫描.
  • 纵向数据收集已经开始,对一小部分参与者进行了最初的18个月的随访.

结论:

  • 头部研究队列是优化AD成像生物标志物的重要贡献.
  • 持续的横截面和纵向数据收集,以及全面的血生物标志物测量,将产生关键的见解.
  • 来自HEAD队列数据的发现将为tau-PET标记物的临床应用提供必要的指导.