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阿尔茨海默氏症成像联盟

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概括
此摘要是机器生成的。

扩散MRI (dMRI) 的协议标准化将扫描器差异最小化,减少协调的需要. 标准化协议使老化和痴呆症生物标志物在不同地点对齐,改善多中心研究数据.

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科学领域:

  • 神经成像和生物医学工程
  • 神经退行性疾病的生物标志物开发.

背景情况:

  • 在多中心研究中,扩散MRI (dMRI) 对衰老和痴呆症生物标志物至关重要.
  • 扫描器间的变化 (供应商,硬件,算法) 可以在dMRI测量中引入系统差异.
  • 协调算法可能会降低数据质量和对生理因素的敏感性.

研究的目的:

  • 测试协议标准化是否能在dMRI中最大限度地减少机器起源差异.
  • 评估标准化是否消除了在多地点研究中获得后协调的需要.
  • 在梅奥诊所长度老化研究 (MCSA) 中评估dMRI指标的可比性.

主要方法:

  • 分析了GE和西门子扫描仪上的交叉数据 (80名参与者),使用不同的协议.
  • 通过使用标准化协议,分析了两个地点 (明尼苏达州,密西西比州) 的MCSA数据 (N=256).
  • 使用组图密度和体基因 (GCC) 测量方法进行dMRI指标 (DTI,NODDI) 的比较.

主要成果:

  • 协议调整 (重新采样,共享b) 减少了交叉数据的分布差异.
  • 标准化MCSA数据显示dMRI (MD,FA) 密度一致,没有显著的GCC差异.
  • NODDI指标显示出比DTI指标更大的特定地点不一致.

结论:

  • 协议和处理标准化有效地减少dMRI中的机器起源差异.
  • 标准化减少了网站间的变化,支持其在协调之前的使用.
  • 与NODDI指标相比,DTI指标对地点差异的敏感性较小.