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阿尔茨海默氏症成像联盟

Ana Bea Solana Sanchez1,2, Brice Fernandez3, David J Lythgoe2

  • 1GE Healthcare, Munich, Bayern, Germany.

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概括
此摘要是机器生成的。

PREDICTOM项目开发了一种协调的MRI协议,以确定阿尔茨海默病的风险. 该协议使用先进的成像技术,在50岁以上的个体中检测早期生物标志物.

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科学领域:

  • 神经成像是一种神经成像.
  • 生物标志物发现发现
  • 人工智能在医学中的应用

背景情况:

  • 由欧盟资助的PREDICTOM项目旨在开发用于早期发现阿尔茨海默病 (AD) 的新生物标志物.
  • 这项研究的重点是建立在七个欧洲临床中心的标准化磁共振 (MR) 成像协议.

研究的目的:

  • 描述PREDICTOM研究的MR协议的理由和设计.
  • 为了能够识别患有阿尔茨海默病的高风险个体.

主要方法:

  • 在七个欧洲中心,为615名50岁以上的健康受试者制定了一项协调的3T MR协议.
  • 该协议是为现代临床MRI扫描仪设计的,从ADNI学习,包括解剖和功能成像.
  • 总检查时间限制在不到一小时,确保在多中心临床环境中可行性.

主要成果:

  • PREDICTOM MRI 协议包含八种数据类型,包括用于微血层检测的定量敏感度映射 (QSM) 和用于早期AD变化的磁共振光谱 (MRS).
  • 适用于低梯度扫描仪的适应包括rsfMRI的部分里埃式扫描仪和减少的2扩散协议.
  • 协议协调正在进行中,最初的测试是在两个供应商和三个模型的四个扫描仪上进行的.

结论:

  • PREDICTOM MR协议旨在探索现有和新型的MRI生物标志物,以早期识别阿尔茨海默病风险.
  • 该协议旨在通过协调努力减少中心和扫描仪之间的偏见.