公共卫生 公共卫生
Patrick S Slama1, Adam R Macbale2, Erin M Jonaitis3,4
1Freelance, Paris, Ile-de-France, France.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
更多的感染与认知能力下降和神经退行性疾病的风险增加有关. 这项研究在威斯康星州阿尔茨海默氏症登记处进行.
科学领域:
- 神经科学是一个神经科学.
- 传染病流行病学 传染病流行病学
- 老年学是指老年学的学科.
背景情况:
- 新兴文献表明,过去的病毒和微生物感染与患阿尔茨海默病和其他神经退行性疾病的风险之间存在联系.
- 最近的研究表明,病毒感染可能在认知表现中起作用.
研究的目的:
- 调查威斯康星州阿尔茨海默氏症预防注册 (WRAP) 队列中感染负担和认知状态之间的关联.
- 探索感染史和认知测试表现之间的关系.
主要方法:
- 从WRAP队列 (超过1500名参与者) 的病史电子表格中分析了病毒,细菌和自身免疫感染的病史.
- 统计分析,包括威尔科克森等级和值,奇方位和回归,比较诊断状态 (痴呆症,轻度认知障碍,无损失-下降) 和认知测试结果,跨感染计数 (0,1,2+).
- 对年龄,性别,APOE状态,教育,种族和访问/测试次数进行控制的分析.
主要成果:
- 观察到积极诊断 (痴呆症,MCI或亚临床损伤) 的参与者比例显著增加,感染数量较高 (21.2%为0个感染,27.6%为1个感染和31.7%为2个以上;p=0.02).
- 与没有感染的参与者 (59秒) 相比,至少有两次感染的参与者在Trails B测试 (72秒) 中的完成时间明显更长.
- 回归分析在调整多个共变量后证实了这些关联的意义.
结论:
- 报告的感染数量与WRAP队列中的认知状态有显著的关联.
- 感染负担与认知表现有关,特别是在Trails B测试中.
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