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阿尔茨海默氏症成像联盟

Beili Shao1,2, Oluwatobi F Adeyemi3, Penny Gowland3

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严重的COVID-19幸存者表现出脑内皮层 (ERC) 体积的减少,类似于早期阿尔茨海默病 (AD) 的变化. 这表明在COVID后的认知功能障碍中存在潜在的神经退行,与AD途径不同,但可能会重叠.

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科学领域:

  • 神经成像是一种神经成像.
  • 神经学 神经学
  • 传染性疾病 传染性疾病

背景情况:

  • 后COVID认知功能障碍是COVID-19的一个显著的肺外并发症.
  • 在COVID-19病例中观察到神经炎症和降低的海马神经发生.
  • 高分辨率的7T核磁共振扫描为早期疾病检测提供了海马子的详细评估.

研究的目的:

  • 在阿尔茨海默氏症 (AD) 和COVID-19后的条件下使用7T MRI探索海马子子子域体积.
  • 为了检查阿尔茨海默病和COVID后疾病之间脑退化的潜在相似之处.
  • 在研究组中使用蒙特利尔认知评估 (MOCA) 评估认知功能.

主要方法:

  • 在四个组中分析海马子场体积:AD患者 (n=32),轻度COVID-19幸存者 (Cv,n=13),严重COVID-19ICU幸存者 (ICU-Cv,n=9),健康对照 (HC,n=29).
  • 使用高分辨率7TMRI进行详细的海马子子子场体积测量.
  • 在所有参与者群体中进行认知评估,包括MOCA.

主要成果:

  • 与HC和Cv相比,阿尔茨海默病患者在多个海马子 (ERC,DG,尾巴,CA) 中表现出显著的缩.
  • 严重的COVID-19幸存者 (ICU-Cv) 与HC相比,体内内皮层 (ERC) 体积减少,而轻度的COVID-19幸存者 (Cv) 显示没有差异.
  • 与ICU-Cv相比,AD患者的ERC和DG体积较小. 在AD中,MOCA得分最低,其次是ICU-Cv,然后是Cv和HC. 与HC相比,ICU-Cv患者在特定领域表现出认知缺陷.

结论:

  • 脑内皮层 (ERC) 对于记忆和导航至关重要,在早期的AD很容易受到影响,并且在严重的COVID-19幸存者中显示选择性缩.
  • 严重的COVID-19可能会通过hyperfusion,炎症或代谢压力等机制诱导向的神经退行,可能与AD重叠.
  • 这些发现突出了在阿尔茨海默氏症和严重的COVID-19后疾病中明显但潜在的融合的神经退行性途径.