公共卫生 公共卫生
Oshadi M Jayakody1, Ying Jin1, Daniel M Aharon1
1Albert Einstein College of Medicine, Bronx, NY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
对阿尔茨海默病临床试验的招聘面临着缺乏兴趣和严格的资格标准等障碍. 解决这些问题可以提高招生率,特别是在多元化的老年人中ADRD研究.
科学领域:
- 老年学是指老年学的学科.
- 临床试验 临床试验
- 神经科学是一个神经科学.
背景情况:
- 阿尔茨海默氏症和相关痴呆症 (ADRD) 临床试验面临着重大招聘挑战,特别是在代表性不足的人群中.
- 这些挑战导致试验延迟,成本增加,科学有效性降低.
研究的目的:
- 检查参与者和与研究相关的在ADRD临床试验中招募的障碍.
- 为未来的招聘策略确定可修改的障碍.
主要方法:
- 来自两项ADRD临床试验的屏幕失效数据的分析,涉及各种老年人.
- 独立评级人员对屏幕故障原因进行系统审查和分类.
- 统计分析以确定参与者特征对屏幕故障概率的影响.
主要成果:
- 62%的屏幕失败与参与者有关 (例如,缺乏兴趣,安排冲突,疾病).
- 与学习相关的原因包括不合格 (57%),学习负担 (19%) 和并发入学 (14%).
- 妇女报告的不信任度更高;少数民族老年人由于符合资格标准而在选中失败的比例不成比例.
结论:
- 确定可修改的与参与者相关的障碍包括缺乏意识和需要可信的信使.
- 与研究相关的策略应包括重新考虑限制性资格标准并提供激励措施.
- 检查社会身份的交叉性对于设计包容性ADRD试验至关重要.
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