公共卫生 公共卫生
Sasha Milton1, Jiahe Wei2, Haizhen Chen2
1University of California, San Francisco, San Francisco, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
循环节律扰乱,以低休息活动节律幅度或 mesor 表示,与65岁以上成年人痴呆风险增加有关. 这表明昼夜变化可能标志着早期痴呆症的发展.
科学领域:
- 时间生物学 时间生物学
- 神经科学是一个神经科学.
- 流行病学 流行病学
背景情况:
- 越来越多的证据将昼夜节律障碍与痴呆风险联系在一起.
- 昼夜变化 (风险因素与前标志物) 的确切作用尚不清楚,特别是在不同年龄段.
- 从中年到老年调查这种关联可以澄清这种关系.
研究的目的:
- 为了检查休息活动节奏 (RAR) 参数与不同年龄层全因痴呆 (ACD) 风险之间的关联.
- 为了确定昼夜节律的干扰是否作为痴呆症的风险因素或前兆标记.
- 探索与痴呆风险相关的RAR参数和年龄之间的潜在相互作用.
主要方法:
- 分析了86,734名没有痴呆症的英国生物库参与者 (42-78岁) 的手腕动图数据.
- 计算RAR参数:振幅,尺度和伪F的计算.
- 按年龄组分层 (≤65,66-70,>70) 和使用Cox模型对发生ACD风险进行比较,并对共变量进行调整.
主要成果:
- 在66-70岁和70岁以上的个体中,RAR幅度和尺度的下四分位数与ACD风险显著增加有关.
- 最低幅度四分位数 (66-70: 1.71; >70: 1.36) 和中等四分位数 (66-70: 2.05; >70: 1.50) 的危险比率较高.
- 对于幅度/尺度的最高四分位数或伪F,没有发现显著的关联;RAR-age相互作用并不显著.
结论:
- 减少休息活动节律幅度和尺度与65岁以上成年人全因痴呆风险较高有关.
- 循环节障碍可能成为老年人群中痴呆症的前兆标记.
- 这些发现强调了昼夜健康在衰老和痴呆症预防方面的重要性.
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