公共卫生 公共卫生
Dominika Seblova1, Jessica Mazen2,3, Justina F Avila2,3
1Second Faculty of Medicine Charles University, Prague, Czech Republic.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
结构性种族主义与英语系拉丁裔成年人白质强度 (WMH) 变化增加有关. 这表明种族主义可能会通过慢性压力和炎症影响脑血管健康.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 社会学 社会学 社会学
背景情况:
- 结构性种族主义是健康的社会决定因素,导致慢性压力和健康差异.
- 以前的研究表明,结构性种族主义与老年人认知能力下降之间存在关联.
- 缺乏关于结构性种族主义如何影响特定大脑结果的证据,特别是在中年和多样化的人口中.
研究的目的:
- 调查结构性种族主义暴露与中年成年人大脑结果之间的关联.
- 检查结构性种族主义是否会缓和年龄和大脑结构性结果之间的关系.
- 探索种族和民族差异,以了解种族主义对大脑健康的影响.
主要方法:
- 分析了398名中年成人 (69%是拉丁裔) 的队列.
- 使用自我报告的歧视和住宅隔离数据创建了高种族主义暴露指数.
- 使用MRI评估了大脑结果,包括皮质厚度,海马体体积和白质超强度 (WMH) 体积.
主要成果:
- 在非拉丁裔黑人 (61%) 和英语系拉丁裔 (42%) 个人中,对种族主义的暴露率最高.
- 在说英语的拉丁人中发现了显著的相互作用:更高的种族主义暴露放大了与年龄相关的白质超强度 (WMH) 体积的增加.
- 对于其他大脑结果或种族/种族群体,没有观察到任何显著的关联.
结论:
- 在这个以拉丁人为主的群体中,更高的种族主义暴露与英语系拉丁人的白质超强度 (WMH) 变化加快有关.
- 这些发现表明,结构性种族主义可能会对脑血管健康产生负面影响,可能由慢性压力和炎症介导.
- 种族主义对大脑健康的影响可能更多地通过血管路径表现出来,而不是直接影响神经元.
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