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阿尔茨海默氏症成像联盟

Andrew R Bender1, Pavithran Pattiam Giriprakash1, Zhengshi Yang1

  • 1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.

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概括
此摘要是机器生成的。

阿尔茨海默病的病理学,以粉样β (Aβ) 表示,改变了白质组织. 新的扩散MRI测量,如纤维分散,显示出与没有痴呆症的老年人Aβ水平和认知功能有很强的联系.

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科学领域:

  • 神经成像是一种神经成像.
  • 神经退行性疾病 神经退行性疾病
  • 生物标志物 生物标志物

背景情况:

  • 阿尔茨海默病 (AD) 与大脑微观结构的变化有关,这些变化可以通过扩散权重磁共振成像 (dMRI) 检测到.
  • 较小,较晚发育的轴突在早期的AD可能是脆弱的,可能通过dMRI测量纤维密度 (FD) 和分散来检测.
  • 这项研究调查了粉样β (Aβ) 是否预测非痴呆老年人的FD和分散差异以及它们与认知的关系.

研究的目的:

  • 用dMRI来确定是否高粉样β (Aβ) 预测白质纤维密度 (FD) 和纤维分散的差异.
  • 评估Aβ相关的微结构参数对没有痴呆症的老年人认知功能的敏感性.
  • 探索纤维分散作为早期阿尔茨海默氏症病理学的新型dMRI生物标志物的实用性.

主要方法:

  • 122名参与者 (认知正常或轻度认知障碍) 接受了多层dMRI和粉样蛋白PET扫描.
  • 使用MRtrix3处理dMRI数据以模拟voxelwise总FD和纤维分散.
  • 质量无变量分析评估了Aβ (半角形水平),预测FD和分散,控制共变量,与非参数家族错误率校正.

主要成果:

  • 较高的Aβ预测了大脑关键区域 (如跨,环膜,海马) 的纤维分散减少,但大脑小区的分散增加.
  • 纤维分散与Aβ百叶状物水平有很强的相关性 (r = -0.78,p < .001).
  • 纤维分散显著预测了多个领域 (例如,记忆,执行功能) 的认知表现,而FD关联较弱,且依赖于年龄/性别.

结论:

  • 粉样β (Aβ) 神经病理与没有痴呆症的成年人白质组织的改变有关.
  • 纤维分散是一种新的dMRI测量方法,与Aβ-PET水平和认知功能高度相关,独立于年龄和性别.
  • 纤维密度和分散的组合建模为早期阿尔茨海默氏症病理学中的微观结构变化提供了补充的见解.