公共卫生 公共卫生
Debora Melo van Lent1,2, Daniel Koijs3,4,5, Josh Bis6
1Framingham Heart study, Framingham, MA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
坚持地中海-DASH干预神经退行性延迟 (MIND) 饮食与痴呆症风险降低有关. 更高的MIND饮食分数也增加了在80岁时保持无痴呆症的可能性.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 观察性研究表明,地中海-DASH干预神经退行性延迟 (MIND) 饮食与降低痴呆风险之间存在联系.
- MIND饮食结合了地中海和DASH饮食的各个方面,专注于大脑健康的食物.
研究的目的:
- 调查MIND饮食得分与发生全因痴呆的风险之间的关联.
- 为了检查MIND饮食分数与80岁时活着,没有痴呆症的概率之间的关系.
主要方法:
- 分析了来自6个社区群体的8,714名没有痴呆症的成年人的数据.
- 使用了Cox和后勤回归模型,并通过元分析结合了结果.
- MIND饮食分数是根据十个健康和五个不健康的饮食成分计算的.
主要成果:
- 更高的MIND饮食得分与所有原因痴呆的风险降低有关 (HR=0.96,95%CI=0.93-0.99).
- 6或更高的MIND饮食得分显示,痴呆风险显著降低 (HR=0.86,95%CI=0.78-0.94).
- 较高的MIND饮食得分与80岁时活着和没有痴呆的几率增加相关 (OR=1.11,95%CI=1.07-1.15).
结论:
- MIND饮食与所有原因痴呆症的风险降低有关.
- 对MIND饮食的更高坚持与在80岁时保持无痴呆症的更大机会有关.
- 建议进行进一步的临床试验,以探索MIND饮食与痴呆病理,包括粉样蛋白和蛋白标志物之间的潜在因果关系.
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