Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

251
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
251
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

212
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
212
Brain Imaging01:14

Brain Imaging

629
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
629
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

460
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
460
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

758
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
758

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Distinct Hippocampal Cellular Pathologies Influence Cognition Across Diagnostic Categories, Also Distinguishing Schizophrenia from Affective Psychoses.

bioRxiv : the preprint server for biology·2026
Same author

Amygdala microstructural changes in subjective cognitive decline: A diffusion kurtosis and neurite orientation dispersion and density imaging study.

Journal of Alzheimer's disease : JAD·2026
Same author

Hypertension is related to a slower radiotracer removal from lateral ventricles.

bioRxiv : the preprint server for biology·2026
Same author

Do Symptom Domains Have Similar Cellular Underpinnings Across Psychiatric Diagnoses: Evidence from 3D Hippocampal MR Spectroscopy.

bioRxiv : the preprint server for biology·2026
Same author

Association of plasma biomarkers with amyloid and tau PET in pre-dementia stages.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

3D foundation model for generalizable disease detection in head computed tomography.

Nature biomedical engineering·2026

相关实验视频

Updated: Jan 8, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

751

阿尔茨海默氏症成像联盟

Ryn Flaherty1, Yu Veronica Sui1, Arjun V Masurkar1,2,3

  • 1NYU Grossman School of Medicine, New York, NY, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
PubMed
概括
此摘要是机器生成的。

扩散性曲解成像 (DKI) 显示了主观认知衰退 (SCD) 个体桃体的微观结构变化. 这些变化,特别是较高的平均化 (MK),与增加的神经细胞密度有关,这表明潜在的树突或质变化.

更多相关视频

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.0K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

40.8K

相关实验视频

Last Updated: Jan 8, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

751
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.0K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

40.8K

科学领域:

  • 神经成像是一种神经成像.
  • 神经退行性疾病 神经退行性疾病
  • 大脑的微观结构

背景情况:

  • 之前的扩散性皮质瘤成像 (DKI) 研究表明,在主观认知衰退 (SCD) 中,杏仁体微观结构发生了变化.
  • 在SCD中,这些DKI变化的特定微观结构驱动因素 (kurtosis分数异位变化 (KFA) 的降低,平均 kurtosis (MK) 的增加) 仍然不清楚.
  • 这项研究调查了DKI指标和来自神经元定向分散和密度成像 (NODDI) 和磁化转移成像 (MTI) 的更具体的微结构标记之间的关联.

研究的目的:

  • 评估桃体中DKI指标 (MK,KFA) 和NODDI (神经质密度[ND],方向分散[OD]) 和MTI (磁化转移比率[MTR]) 指标之间的关系.
  • 阐明SCD中之前观察到的DKI变化的微结构基础.
  • 为了确定不同成像技术对桃体SCD变化的敏感性.

主要方法:

  • 175名55-88岁的参与者 (75人患有SCD) 接受了DKI,NODDI和MTI.
  • DKI提供了MK,辐射曲解 (RK),轴向曲解 (AK) 和KFA.
  • NODDI提供了ND和OD;MTI提供了MTR. 计算了双边杏仁体的平均值,并使用线性模型检查了相关性.

主要成果:

  • 与对照人群相比,SCD个体在右桃体中表现出较低的KFA,更高的MK和更高的RK.
  • KFA与ND的负相关性很弱;MK和RK与ND的正相关性很强.
  • MK与OD有微弱的正相关性,但DKI指标和MTR之间没有发现显著的相关性.

结论:

  • DKI指标比NODDI或MTI更敏感于SCD中的杏仁体变化.
  • 观察到的关联表明,神经元密度增加 (树突或质分支) 是SCD中更高的MK和RK的基础.
  • 较高的MK也可能表明神经细胞组织减少 (较高的OD),这需要进一步调查与SCD相关的神经心理症状.