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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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阿尔茨海默氏症成像联盟

Pulkit Khandelwal1,2, Sydney A Lim2, Wilma D J Van de Berg3,4

  • 1Penn Image Computing and Science Laboratory (PICSL), University of Pennsylvania, Philadelphia, PA, USA.

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概括
此摘要是机器生成的。

我们开发了一种新的管道,可以准确地分割和记录高分辨率的体外核磁共振成像 (ex vivo MRI) 与现场核磁共振成像 (in situ MRI). 这种方法使得在痴呆症研究中大脑形态测量和组织病理学之间有更强的关联.

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科学领域:

  • 神经成像是一种神经成像.
  • 计算解剖学的计算解剖学
  • 医学图像分析 医学图像分析

背景情况:

  • 痴呆症研究在将病理与混合病因和非典型阿尔茨海默病联系起来方面面临挑战.
  • 由于时间延迟,在体内MRI和尸检之间的差距很难弥合.
  • 活体MRI提供更高的分辨率,但受固定和变形的影响.

研究的目的:

  • 呈现一个全半球的ex vivo到in situ/in vivo分片和注册管道,命名为"紫MRI".
  • 为了实现死后MRI的多分辨率和临床相关登记.
  • 为了促进形态测量和病理学之间的更强的关联研究.

主要方法:

  • 结合深度学习细分与基于表面的建模,用于使用DKT地图的ex vivo半球分片.
  • 在ex vivo和in situMRI之间开发了一种两阶段的diffeomorphic图像注册方法.
  • 使用FreeSurfer进行DKT基于地图的在位MRI的细分.

主要成果:

  • 产生了ex vivo半球的定性分片,并记录了in situMRI.
  • 该方法成功地将脑部区域与成像器件分割成部分.
  • 在ex vivo和in situMRI之间观察到区域性体积和平均厚度的显著相关性,特别是在时间和轨道前额区域.

结论:

  • "紫MRI"管道准确地分割高分辨率的外体MRI并将其注册到in situMRI.
  • 该管道建立了多模模式死后MRI之间的一对一对应.
  • 这项工作为ex vivo到in vivo注册铺平了道路,增强了与痴呆症相关的关联研究.