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Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
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阿尔茨海默氏症成像联盟

Xiaqing Jiang1, Sid E O'Bryant2, Robert A Rissman3

  • 1University of California, San Francisco, San Francisco, CA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
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概括

多种慢性疾病,具有多种慢性疾病,与较差的认知和阿尔茨海默病 (AD) 病理,神经退行和脑小血管疾病 (SVD) 的增加有关. 这些情况可能会通过神经退行性和AD相关途径影响认知衰老.

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科学领域:

  • 神经学 神经学
  • 老年学是指老年学的学科.
  • 公共卫生 公共卫生

背景情况:

  • 多种疾病,多种慢性疾病的存在,越来越被认为是认知衰老的重要因素.
  • 将多病症与认知衰退,阿尔茨海默病 (AD) 和相关痴呆症联系在一起的确切机制仍然不完全理解.

研究的目的:

  • 调查老年人多病症负担和认知功能之间的关联.
  • 探索阿尔茨海默病 (AD) 病理,神经退行和脑小血管疾病 (SVD) 在这种关系中的调解作用.

主要方法:

  • 一项对2951名年龄在50岁及以上的没有痴呆症的参与者进行的横截面研究,来自"健康与衰老大脑研究:健康差异"队列.
  • 多重疾病负担是通过计算慢性疾病的数量来量化. 认知功能的评估是使用神经心理测试中的潜在因子得分进行的. 用PET,血测定和MRI测量了AD病理,神经退行和SVD的生物标志物.
  • 使用线性回归和结构方程建模 (SEM) 来分析关联和介导路径.

主要成果:

  • 更高的多病症负担与更糟糕的整体认知显著相关.
  • 增加的多病症也与AD病理,神经退行和SVD的生物标志物升高有关.
  • 结构方程建模表明,多病症和认知衰退之间的关联主要由神经退行症 (74%) 和AD病理学 (22%) 介导.

结论:

  • 在没有痴呆症的个体中,多病症的较大负担与AD病理,神经退行和SVD的不良生物标志物有关.
  • 多病症似乎通过涉及神经退行和AD病理学的途径对认知产生负面影响,突出了干预的潜在目标.