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阿尔茨海默氏症成像联盟

Sulakshna Aggarwal1, Priya Chatterjee2, Hitesh Pradhan2

  • 1Centre for Brain Research, Bangalore, Karnataka, India.

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概括
此摘要是机器生成的。

高水平的homocysteine与农村印度人的认知能力下降有关,无论维生素B12状态如何. 早期的homocysteine查可能有助于识别患有认知障碍风险的个体.

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科学领域:

  • 神经学 神经学
  • 营养神经科学 营养神经科学
  • 衰老研究研究 衰老研究

背景情况:

  • 维生素B12对认知功能产生影响,可能是通过同型半氨酸水平.
  • 印度农村地区对维生素B12,同类氨酸和认知/大脑变化的数据有限.

研究的目的:

  • 为了调查维生素B12,同型半氨酸和印度农村老龄化人口的认知表现之间的联系.
  • 探索这些生物标志物与MRI定义的大脑体积之间的关系.

主要方法:

  • 从CBR-SANSCOG队列中对2784名非痴呆症参与者 (45岁以上) 的横截面分析.
  • 使用HMSE和COGNITO电池进行认知评估;对大脑体积进行MRI.
  • 统计分析 (一般线性模型) 调整为多个共变量.

主要成果:

  • 维生素B12水平与认知表现或大脑体积之间没有发现任何关联.
  • 增加的同类半氨酸水平与较低的HMSE和视觉注意力得分相关.
  • 较高的homocysteine与海马体积的减少有关,独立于维生素B12.

结论:

  • 在这个人群中,高水平的homocysteine会对认知表现产生负面影响,无论维生素B12的含量如何.
  • 血清homocysteine查可以识别患有认知衰退风险的个体.
  • 同类氨酸可以作为早期认知障碍检测的生物标志物.