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阿尔茨海默氏症成像联盟

Quentin Devignes1, Patrick J Pruitt1, Kenneth Petscavage1,2

  • 1University of Michigan, Ann Arbor, MI, USA.

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概括
此摘要是机器生成的。

阿尔茨海默病 (AD) 中的神经精神症状 (NPS) 与突出网络中的微观结构灰质变化有关,而不是粉样蛋白或负担. 这些发现表明,NPS的严重程度与AD病理学相比,与大脑结构的改变更多相关.

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科学领域:

  • 神经科学是一个神经科学.
  • 神经学 神经学
  • 医疗成像医学成像

背景情况:

  • 神经精神症状 (NPS) 是阿尔茨海默病 (AD) 的核心特征.
  • 突出网络中的功能连接中断与NPS严重程度有关.
  • 在AD中NPS的结构和病理基础需要进一步调查.

研究的目的:

  • 调查NPS严重程度与灰质 (GM) 微观结构完整性之间的关系.
  • 检查NPS严重程度与粉样蛋白和陶负担在轻度认知障碍 (MCI) 和轻度AD痴呆症 (DAT) 患者中的关联.

主要方法:

  • 178名患有MCI或DAT的参与者接受了PET扫描,检测粉样蛋白 ([11C]-匹兹堡化合物B) 和 ([18F]AV-1451) 沉积.
  • 使用神经元定向分散和密度成像 (NODDI) 的扩散张力成像 (DTI) 评估了GM微结构完整性 (NDI,ODI).
  • 沃克塞尔智能回归分析与NPS严重程度 (NPIQ分数) 与PET和DTI测量相关,控制年龄,性别和教育.

主要成果:

  • 较高的NPS严重程度与右侧胰岛和下额回形的方向分散指数 (ODI) 降低相关,表明微观结构完整性发生了变化.
  • 在NPS严重程度和粉样蛋白或蛋白负担之间没有发现显著的关联.
  • 一个温和的值揭示了NPS严重程度和左条体中沉积增加之间的潜在关联.

结论:

  • 在AD中,NPS的严重程度与突出网络区域的白质扩散性变化有关,这可能反映了树突复杂性的减少.
  • 微观结构上的灰质变化,而不是粉样蛋白或负担,可能与阿尔茨海默氏症中NPS严重程度更密切相关.
  • 这些发现支持了在AD的背景下,突出网络在NPS中的作用.