公共卫生 公共卫生
Raphael Machado Castilhos1, Natan Feter2, Ana Luísa Patrão3
1Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
早期更年期和更长的月经持续时间与更快的认知衰退有关. 在ELSA-巴西的这项研究强调了女性潜在的痴呆症风险因素.
科学领域:
- 神经科学是一个神经科学.
- 生殖内分泌学 生殖内分泌学
- 流行病学 流行病学
背景情况:
- 关于早期更年期 (EM) 和总月经时间 (menacme) 作为痴呆症风险因素,存在相互矛盾的证据.
- 成人健康的纵向研究 (ELSA-巴西) 旨在澄清这些关联.
研究的目的:
- 评估早期更年期 (更年期≤45岁) 作为认知能力下降的风险因素.
- 评估总月经时间 (menacme) 与认知能力下降之间的关联.
主要方法:
- 分析了来自15105名ELSA-巴西参与者的数据 (2008-2010年),重点是8218名女性.
- 认知功能大约在8年后被评估.
- 使用了根据年龄和痴呆症风险因素调整的混合线性模型.
主要成果:
- 31.3%的已停止月经的妇女报告了早期更年期.
- 早期更年期的女性更年期持续时间较短.
- 早期更年期和更长时间的更年期在8年内独立地与更快的认知衰退有关.
结论:
- 早期更年期和更长时间的更年期与加速的认知衰退有关.
- 这些生殖因素可能是痴呆症风险评估的重要目标.
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