公共卫生 公共卫生
Xiaowen Zhou1,2,3, Hanzhi Deng4, Qianhua Zhao1,2,3
1Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
随着COVID-19的流行,老年人的认知能力下降加速了,尤其是那些有现有健康问题的人. 这项研究分析了上海居民在疫情封锁之前和之后的认知变化.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 流行病学 流行病学
背景情况:
- COVID-19 流行病对健康构成威胁,对老年人有潜在的认知影响.
- 上海严格的封锁 (2022年4月至5月) 提供了一个独特的环境来研究大流行对认知的影响.
- 居住在社区的老年人是理解认知衰退风险的焦点.
研究的目的:
- 调查COVID-19大流行对社区老年人的认知衰退的影响.
- 为了比较上海居民在疫情封锁之前和之后的认知变化.
- 确定影响流行后加速认知衰退的因素.
主要方法:
- 长度队列研究 (上海老龄化研究) 对3792名年龄≥50岁的居民 (2009-2024年).
- 使用迷你心理状态检查 (MMSE) 和特定领域测试评估认知功能.
- 统计模型 (事件研究,差异差异,混合效应) 分析了大流行对认知衰退的影响.
主要成果:
- 与流行病前时期相比,在流行病后的几年 (2022-2024) 观察到的MMSE得分下降更为急剧.
- 在流行病后的参与者中发现MMSE显著下降 (波3) 与基线相比,在流行病前没有变化 (波2).
- 在早期出生队伍中,那些具有高基线p-tau生物标志物,APOE4载体,并发症和药物使用的人群中,下降更为明显.
结论:
- 随着COVID-19的流行,上海老年人的认知能力下降显著加速.
- 患有先前存在的神经退行性疾病或精神健康问题的个人表现出更大的脆弱性.
- 研究结果强调了大流行对老年人群认知健康的有害影响.
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