公共卫生 公共卫生
Holly C Elser1, Erzsébet Horváth Puhó2, Cecilia Hvitfeldt Fuglsang2
1Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
患有痴呆症的人面临着持续更高的中风风险,包括缺血性中风,脑内出血和脑下出血. 这凸显了在痴呆症患者中主动管理血管风险因素的需要.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 脑卒中是认知障碍的常见原因,而痴呆症在中风患者中普遍存在.
- 对先前痴呆症患者中风发病率的研究是有限的,结果各不相同.
研究的目的:
- 调查在被诊断患有痴呆症的个人中全国性中风的发生率.
- 为了比较痴呆症患者中风风险与普通人群.
主要方法:
- 一项基于人口的全国性队列研究,使用丹麦登记数据 (1996-2021年).
- 鉴定了35岁以上的痴呆症患者和以前没有中风的个人,与没有痴呆症的对照人群相匹配1:3.
- 使用考克斯比例危险回归来计算缺血性中风,脑内出血 (ICH) 和大脑下下垂体出血 (SAH) 的危险比在诊断后的1,5年和10年.
主要成果:
- 这项研究包括158,725名痴呆症患者和476,170名匹配对照.
- 痴呆症患者患有缺血性中风的风险较高 (1年HR=1.63,10年HR=1.15).
- 痴呆症诊断与ICH (1年HR=2.69,10年HR=1.92) 和SAH (1年HR=2.71,10年HR=1.52) 的风险显著增加.
结论:
- 与一般人群相比,被诊断患有痴呆症的个人表现出所有类型中风的持续升高风险.
- 这些发现强调了在患有痴呆症的人群中对血管风险因素的积极管理的关键需求.
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