公共卫生 公共卫生
Jason R Richardson1, Isha Mhatre-Winters1, Piera Cirillo2
1Isakson Center for Neurological Disease Research, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 23, 2025
概括
产前暴露于杀虫剂DDT代谢物DDE与关键阿尔茨海默氏症生物标志物的较低水平和中年较差的认知功能有关. 这表明DDT/DDE暴露可能会增加阿尔茨海默氏症和相关痴呆症 (ADRD) 的风险.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 环境暴露越来越多地被认为是阿尔茨海默氏症和相关痴呆症 (ADRD) 的危险因素.
- 以前的研究将较高的血清DDE (一种持久的DDT代谢物) 与阿尔茨海默氏症风险增加和认知能力下降有关.
- 动物研究表明DDT/DDE降低了认知功能,增加了粉样蛋白病理,低血Aβ42/40比率表明了这一点.
研究的目的:
- 调查产前DDE暴露对人体血氨基酸β (Aβ) 水平和认知功能的影响.
- 评估产前DDE暴露与中年认知表现和Aβ 42/40比率之间的关联.
主要方法:
- 利用了儿童健康和发育研究 (CHDS) 妊娠队列 (1959-1963) 的数据.
- 在179名参与者中使用数字符号测试 (DSST) 评估中年认知功能,并测量了179名参与者的血Aβ 42/40比率.
- 用一般线性回归模型在存档的母体血清中测量了产前p,p'-DDE水平,并分析了使用一般线性回归模型的关联.
主要成果:
- 产前的p,p'-DDE水平与较低的中年血Aβ 42/40比率 (β = -0.37,p = 0.03) 有意义地相关.
- 产前较高的p,p'-DDE水平与中年期的DSST表现较差相关 (β = -0.020,p = 0.02).
- 在对共变量进行调整后,这些关联仍然很强.
结论:
- 产前暴露于p,p'-DDE与改变的Aβ 42/40水平和中年认知功能受损有关.
- 识别DDT/DDE暴露率较高的人群可能有助于确定患ADRD风险较高的个体.
- 对于那些有ADRD进展风险的人来说,可以制定早期干预和预防策略.
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